Recombinant Rat Interleukin-1 alpha (Il1a)

1. Extracellular high-mobility group box-1 (HMGB1) was identified as the likely endogenous regulator of IL1 expression after injury PMID:26899371
2. IL-1alpha-induced expression of C/EBPbeta and SDF-1 was significantly potentiated by knockdown of transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of IKKbeta signaling, in vascular smooth muscle cells. PMID:26002466
3. There is increased expression of Il-1alpha in the spinal cord 1 day after painful facet joint injury. PMID:24253784
4. It can be concluded that GERD with increased cytokines and inflammatory cells in lung could cause or exacerbate asthma and pulmonary fibrosis. PMID:24338227
5. The findings of the present study suggest that part of ischemic injury in the embolic stroke may be mediated through the increased levels of inflammatory cytokines. PMID:24338258
6. Streptococcus pneumoniae infection promotes atherogenesis and exacerbates inflammatory responses to cerebral ischemia, leading to increased brain injury via platelets and interleukin (IL) 1. PMID:24644058
7. Therefore, systemic modulation of the immune response by hUCB cells could represent one possible mechanism of how these cells might mediate their beneficial effects. PMID:23123184
8. Sertoli cells treated with IL-1alpha revealed changes in cellular distribution of actin filaments compared to untreated cells. Increase in the kinetics of occludin internalization but decrease in its rate of degradation was noted following IL-1alpha treatment. PMID:21191089
9. Regulatory enhancer binding protein transcription factor AP-1 binding to the IL1A -889 polymorphic locus has been characterized. PMID:22634325
10. Data show that MDMA produces changes in IL-1 signal modulators which are modified by CB2 receptor activation, and indicate that IL-1beta may play a partial role in MDMA-induced neurotoxicity. PMID:21595923
11. Abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level. PMID:20529813
12. data demonstrate that the cyclooxygenase 2 cascade is a regulator of IL-1 alpha,IL-1 beta and IL-6 mRNA in Leydig progenitors PMID:12193539
13. produced in and secreted by rat testis PMID:12270120
14. the changes of IL-1 and NO levels in the testes of rats with varicocele might be the reason which caused testes damage, disturbance of spermatogenesis and even infertility. PMID:12479028
15. there is a differential expression of calpain I and II under pathological conditions induced either by endotoxin stimuli or Leydig cell depletion, which may produce a differential effect on IL-1alpha processing. PMID:12534936
16. Lipopolysaccharides (endotoxins) stimulate expression of this inflammatory cytokine in skeletal muscle. PMID:12785009
17. IL-1alpha and IL-2 produce an increase of glucose metabolism in uteri isolated from underfed rats PMID:12878449
18. Interleukin-1alpha produces an increase of glucose metabolism in uteri isolated from underfed rats by two different mechanisms, both involving COX-2: (1) nitric oxide independent and (2) nitric oxide dependent PMID:14643175
19. Data suggest that gamma-hexachlorocyclohexane-induced liver oxidative stress triggers DNA binding activity of NF-kappaB, with a consequent increase in expression of NF-kappaB-dependent genes for tumor necrosis factor-alpha and interleukin-1alpha. PMID:15025948
20. This review summarizes the findings in rats that isoforms of IL-1alpha may serve as paracrine mediators, alone or in concert with other factors, that support proper testicular cell functioning and, thereby, reproduction and fertility. PMID:15032628
21. We conclude that the pro-inflammatory cytokines IL-1beta and TNFalpha inhibit electrogenic sodium absorption in rat distal colon by mRNA expression regulation of the beta- and gamma-ENaC subunits. PMID:15063785
22. interleukin-1alpha (IL-1alpha) is a proinflammatory cytokine that has also been found to act as a paracrine mediator involved in the regulation of testicular functions [review] PMID:15154090
23. sympathetic nerves have an inhibitory effect on IL-1 alpha in periapical lesions and a stimulatory effect on TNF-alpha in the intact rat pulp. PMID:15467353
24. The differential effects of recombinant rat IL-1 alpha and IL-1 beta on mouse cultured glial cells are mediated by alternative pathways to the classical IL-1 signaling cascade. PMID:15671867
25. the IL1A and il10 genesw are substantially related to the development of cat exposure-induced allergy PMID:15990800
26. These results show that IL-1alpha and IL-1beta play important roles in the TBI-induced loss of hippocampal neurons. PMID:16083355
27. The increased expression of IL-1alpha and IL-1beta in varicocele shifts the balance in favor of inflammatory and immune responses and causes detrimental effects in testis tissue, which may cause male infertility. PMID:16616101
28. Normal IL-1 signaling is required for the production of brain PGE(2) under basal conditions and in response to surgical stress. PMID:16825798
29. Tyr-542 of SHP-2 modulates IL-1-induced Ca2+ signals and association of the ER with focal adhesions PMID:16905534
30. IL-1 is the proinflammatory mediator responsible for the reduced level of phosphorylated eIF4G PMID:17117141
31. Functionally active IL-1alpha is present on the cell surface of neonatal rat cardiomyocytes suggesting a differential role of IL-1alpha in regulation of cellular functions during development, aging and disease in rat and human heart cells. PMID:17621543
32. Localized production of IL1A by Sertoli and/or germ cells in vivo results in BTB restructuring. PMID:18057314
33. IL-1alpha was significantly more efficient than IL-1beta at up-regulating SP expression than IL-1beta. Taken together, these observations suggest an important role for IL-1alpha in the events following nerve injury. PMID:19341730
34. Bacterial lipopolysaccharide increased the production of interleukin 1alpha and activin A, and reduced production of inhibin B, in Sertoli cells from immature male rats. PMID:19524137
35. Data show that with the help of negative regulators TGF-beta and FasL, the high levels of IL-1alpha and IL-6 expressions were observed in the early stages of the infection, and decreased gradually in the later weeks both in vitro and in vivo. PMID:19567205

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UNIGENE: Rn.12300

KEGG: rno:24493

STRING: 10116.ENSRNOP00000006113