Recombinant Rat Integrin alpha-7 (Itga7), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Itga7

Purity

>85% (SDS-PAGE)

Target Names

Itga7

Uniprot NO.

Q63258

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation.

Gene References into Functions

The laminin-binding integrin alpha7beta1 is oxidized by hydrogen peroxide at specific sites and thereby redox regulated in its binding activity. PMID:22659335
alpha7beta1 integrin is a Schwann cell receptor for laminin-2. PMID:17598176
Alpha(7)beta(1) integrin is a potential receptor for COMP. The protective effects of COMP are mainly mediated through interaction with alpha(7)beta(1) integrin. PMID:20019333
the distribution of alpha 7 integrins in series-fibred muscles suggests they are involved in transmission of tension from intrafascicularly terminating fibres to neighbouring fibres PMID:12037582
Chemical injury induced by allylamine significantly enhances alpha(7)-integrin expression in vascular smooth muscle cells. PMID:14988073
Results indicate that platelet-derived growth factor enhances alpha(7)-integrin expression in vascular smooth muscle cells and promotes alpha(7)-integrin-mediated adhesion to laminin. PMID:16282198
cleavage is a novel mechanism that regulates alpha7 integrin functions in skeletal muscle, and that the generation of such cleavage sites is another evolutionary mechanism for expanding and modifying protein functions. PMID:18940796

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Integrin alpha chain family

Tissue Specificity

Expressed in skeletal and cardiac muscle. Expressed in replicating myoblasts. In differentiated muscle fibers localizes between fibers and the surrounding matrix. Isoform Alpha-7X1A and isoform Alpha-7X1B are expressed at myotendinous and neuromuscular ju

Database Links

UNIGENE: Rn.54492

KEGG: rno:81008

STRING: 10116.ENSRNOP00000058370

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