Recombinant Rat Integrin alpha-1 (Itga1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Itga1

Uniprot NO.

P18614

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

Gene References into Functions

periodic mechanical stress induced ECM expression and the migration of NP cells via upregulating the expression of integrin alpha1 and the phosphorylation of downstream PLCgamma1. These findings provide novel information to aid the understanding of the pathogenesis and development of IDD. PMID:27484337
This study shows that E2 protects against apoptosis in a time-dependent manner, and alpha1 integrin-mediated adhesion to collagen II is essential for estrogen-dependent anti-apoptosis in rat annulus fibrosus cells in vitro. PMID:27108411
Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects on vascular smooth muscle cell proliferation/migration. PMID:26520903
Dynamic structural changes are observed upon collagen and metal ion binding to the integrin alpha1 I domain. PMID:22847004
Data suggest that endothelin-1 promotes collagen matrix reorganization through the enhancement of mesangial cell alpha1beta1 integrin-dependent migration and MMP-2 activity. PMID:12459174
Pretreatment of mature hippocampal neurons with either echistatin or alpha(1) integrin-blocking antibodies prevented beta-amyloid-induced MAPK activation. The blockage of alpha(1) activation prevented cell death induced by beta-amyloid. PMID:14991844
After spinal cord contusion, the area of alpha1beta1 integrin positive blood vessels increases within 11 mm from the injury site at 3 days post-injury and remains prominent within the injured core only at 7 days. PMID:17161391
Alpha(1)beta(1)-integrin has a key role in flow (shear stress)-dependent vasodilation in resistance arteries by transmitting the signal to eNOS through activation of PI3-kinase and Akt. PMID:18245559