Recombinant Rat Indoleamine 2,3-dioxygenase 1 (Ido1)

1. Results show the antidepressant effect of infliximab and suggest that its mechanism is partly related to inhibition of indoleamine 2, 3-dioxygenase/3-hydroxyl amino acid oxygenase pathway activation mediated by tumor necrosis factor-alpha in rat brain. PMID:27366867
2. this study suggests a link between melatonin, JNK, FoxO1 and IDO1 that acts as a potential balance regulator of tryptophan metabolism, and offers a new approach to treat diseases related to dysregulation of tryptophan metabolism PMID:28118532
3. results suggest that M30 is neuroprotective against CORT-induced depression targeting elevated MAO activities that cause oxidative stress and neuroinflammation, resulting in IDO-1 activation, serotonin deficiency and neurodegeneration. PMID:27870896
4. IDO expression in NSCs synergistically potentiates the immune suppression activities of NSCs and could be applicable for the development of therapeutic modalities against various neurodegenerative diseases. PMID:26636969
5. study demonstrates that IDO gene transfer into engineered lung allograft tissues significantly attenuates acute allograft damage suggesting local therapy with IDO as a strategy to reduce need for systemic immunosuppression and, thereby, its side effects PMID:26506443
6. Indoleamine 2,3-dioxygenase is upregulated in the brain of rats with acute pancreatitis. PMID:25829217
7. inhibitory effect of locally delivered CTLA4Ig is dependent on IDO activities within the allograft. PMID:25498102
8. Transfer of tolerance to naive recipients is dependent upon IDO-mediated immunosuppression. Initiators of IDO activity, CTLA-4 or soluble CTLA-4 did not mediate this tolerogenic process. PMID:23607691
9. results suggest IDO gene expression correlates with the severity of acute rejection and IFN-gamma induced IDO-positive DCs may attenuate acute rejection and catalyze local tryptophan metabolism via IDO enzyme expression,leading to tolerance after liver transplantation PMID:22454246
10. Ido1 gene knockout or pharmacological inhibition of hippocampal IDO1 activity attenuated both nociceptive and depressive behavior PMID:22751107
11. zebularine plus interferon gamma induce IDO1 gene expression related to demethylation events in the IDO1 promoter region and to up-regulation of expression of transcription factors PMID:22424783
12. Detection of IDO mRNA in peripheral blood diagnosed acute rejection in the rat model at an earlier stage. PMID:22172881
13. Data suggest that during the first phase of infection the IDO-mediated tryptophan depletion has a predominantly antimicrobial effect. PMID:19602041
14. NK cells expression is associated with liver allograft acceptance PMID:19944758
15. HO-1/IDO cross-regulation modulates apoptosis and proliferation in rat and human breast cancer cells PMID:16319139
16. In conclusion, this study demonstrates an age-related decline in Cu/Zn-SOD and IDO activities, the two enzymes responsible for scavenging O2*-. PMID:16688932
17. Report immunological role of indoleamine 2,3-dioxygenase in rat liver allograft rejection and tolerance. PMID:17645734
18. CD4+T cells accumulate at the heart transplant site and induce graft endothelial cell expression of Indoleamine 2, 3-dioxygenase (IDO) PMID:17868070
19. IDO inhibition for 7 days after transplantation reduces survival, but does not cause acute rejection of the liver in an immunotoleramt model. PMID:18475196
20. gene delivery using IDO was unsuccessful in prolonging rat liver allograft survival. PMID:19177450
21. In vitro, the proliferative ability of T cells or B cells from experimental autoimmune myastenia gravis rats was inhibited when they were cocultured with bone marrow stromal cells. This inhibitory effect was partially dependent on the secretion of IDO PMID:19283707
22. Liver-induced long-term acceptance seen in human combined auxiliary liver and kidney transplantation is at least partly mediated by InDO activity. PMID:19935463

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UNIGENE: Rn.64513

KEGG: rno:66029

STRING: 10116.ENSRNOP00000050320