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Recombinant Rat Hypoxia up-regulated protein 1 (Hyou1), partial

Recombinant Rat Hypoxia up-regulated protein 1 (Hyou1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Hyou1

Purity

>85% (SDS-PAGE)

Target Names

Hyou1

Uniprot NO.

Q63617

Alternative Names

Hyou1; Orp150; Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; ORP-150

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

33-999

Target Protein Sequence

LAVMSVDL GSESMKVAIV KPGVPMEIVL NKESRRKTPV TVTLKENERF LGDSAAGMAI KNPKATLRYF QHLLGKQADN PHVALYRSRF PEHELNVDPQ RQTVRFQISP QLQFSPEEVL GMVLNYSRSL AEDFAEQPIK DAVITVPAFF NQAERRAVLQ AARMAGLKVL QLINDNTATA LSYGVFRRKD INSTAQNIMF YDMGSGSTVC TIVTYQTVKT KEAGTQPQLQ IRGVGFDRTL GGLEMELRLR EHLAKLFNEQ RKGQKAKDVR ENPRAMAKLL REANRLKTVL SANADHMAQI EGLMDDVDFK AKVTRVEFEE LCADLFDRVP GPVQQALQSA EMSLDQIEQV ILVGGPTRVP KVQEVLLKPV GKEELGKNIN ADEAAAMGAV YQAAALSKAF KVKPFVVRDA VIYPILVEFT REVEEEPGLR SLKHNKRVLF SRMGPYPQRK VITFNRYSHD FNFHINYGDL GFLGPEDLRV FGSQNLTTVK LKGVGESFKK YPDYESKGIK AHFNLDESGV LSLDRVESVF ETLVEDSPEE ESTLTKLGNT ISSLFGGGTS SDAKENGTDA VQEEEESPAE GSKDEPAEQG ELKEEAEAPM EDTSQPPPSE PKGDAAREGE TPDEKESGDK SEAQKPNEKG QAGPEGVPPA PEEEKKQKPA RKQKMVEEIG VELAVLDLPD LPEDELAHSV QKLEDLTLRD LEKQEREKAA NSLEAFIFET QDKLYQPEYQ EVSTEEQREE ISGKLSATST WLEDEGFGAT TVMLKDKLAE LRKLCQGLFF RVEERRKWPE RLSALDNLLN HSSIFLKGAR LIPEMDQIFT DVEMTTLEKV INDTWTWKNA TLAEQAKLPA TEKPVLLSKD IEAKMMALDR EVQYLLNKAK FTKPRPRPKD KNGTRTEPPL NASAGDQEEK VIPPTGQTEE AKAILEPDKE GLGTEAADSE PLELGGPGAE SEQAEQTAGQ KRPLKNDEL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Gene References into Functions

Data reveal that Grp170 participates in preparing mutant proinsulin for degradation while enabling wild-type proinsulin escape from the endoplasmic reticulum. PMID:28028074
Results imply a probable role of ORP150 in the changes in appearance and function of pancreatic beta cells following acute necrotizing pancreatitis, through the pathway of endoplasmic reticulum stress. PMID:21536389
role for the protein both in preventing cardiomyocyte death and in preserving contractile function after ischemic damage PMID:15733911
ER stress proteins (GRP78 and ORP150), respectively) were upregulated at PTCs in experimental proteinuric rats. PMID:16955111
These data reveal a novel cellular localization for ORP150 and that mitochondrial ORP150 is upregulated by CHOP/GADD153 in response to mitochondrial and ER stress. Our data also reveal that ORP150 is a substrate for mitochondrial calpain 10. PMID:18094145