Recombinant Rat Histone deacetylase 4 (Hdac4), partial

1. the present study demonstrated that resveratrol attenuated AngIIinduced cell proliferation and neointimal hyperplasia by inhibiting the CaMKIIHDAC4 signaling pathway. These findings suggest that resveratrol may potentially prevent arterial restenosis. PMID:29845301
2. These results suggest that HDAC4 and HDAC8 may serve as key upstream mediators of MAPK in regulating the IL1betainduced cartilage catabolic and degradation. PMID:29393346
3. HDAC4 regulates thimerosal-induced cell death in neurons and that treatment with MC1568 prevents thimerosal-induced activation of caspase-3 in the rat prefrontal cortex. PMID:27660204
4. Our data suggest that nuclear HDAC4 accumulation in skeletal muscle is partly related to immobilization-induced muscle atrophy. PMID:26759025
5. Cx43 and HDAC4 mRNA expression first decreased and then increased compared to that in the control group; differences in HDAC4 mRNA expression were significant in the 1-week group. PMID:27706732
6. Phosphorylation of HDAC4 was remarkably upregulated after stroke and blockade of HDAC4 phosphorylation with GO6976 repressed stroke-induced angiogenesis. Phosphorylation of HDAC4 was also increased in endothelial cells hypoxia model and suppression of HDAC4 phosphorylation inhibited the tube formation and migration of endothelial cells in vitro. PMID:28127553
7. Melatonin -exhibited anti-allodynia is mediated by MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to induce HDAC4 dephosphorylation and nuclear import, herein increases HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1 expression in dorsal horn neurons. PMID:26732138
8. chromatin immunoprecipitation experiments showed that NFAT1-HDAC4 or NFAT3-HDAC4 complexes might be involved in regulation of PMCA2x splicing variant generation. PMID:24905014
9. Neuropathic pain maintenance involves spinal HDAC4 phosphorylation and retention in dorsal horn neurons. PMID:25871743
10. Stroke induces nuclear shuttling of HDAC4 in neurons in the peri-infarct cortex. PMID:25967576
11. Thus, HDAC4 contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy. PMID:24717296
12. Results highlight the unique nature of molecular signatures evoked by postnatal fluoxetine, and implicate HDAC4 in the dysregulated gene expression and emergence of perturbed emotionality following fluoxetine exposure in early life PMID:24663010
13. We examined whether HDAC4 controls vascular smooth muscle cell proliferation and migration. PMID:24166750
14. Oncogenic K-Ras modulates expression and localization of catenin and HDAC4 proteins in Rat2 cells. PMID:23747726
15. Nuclear exit of HDAC4 was prevented by downregulation of Nox4 in cultured neonatal rat cardiomyocytes. PMID:23271793
16. HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. PMID:22389387
17. cardiac hypertrophy pathological changes were largely blunted by silencing the CaMKIIdeltaA gene and an underlying mechanism indicated selective interference with the HDAC4-MEF2 signaling pathway. PMID:21554860

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UNIGENE: Rn.23483

KEGG: rno:363287

STRING: 10116.ENSRNOP00000027622