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Recombinant Rat Hepatocyte nuclear factor 3-beta (Foxa2)

Recombinant Rat Hepatocyte nuclear factor 3-beta (Foxa2)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Foxa2

Uniprot NO.

P32182

Alternative Names

Foxa2; Hnf3b; Tcf-3b; Tcf3bHepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Forkhead box protein A2

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-458

Target Protein Sequence

MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNASLGMNGM NTYMSMSAAA MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM SGSAGAAGVA GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDFLKVP RAPDKPGKGS FWTLHPDSGN MFENGCYLRR QKRFKCENEL ALKEAAGAGS GGGKKTAPGT QASQVQLGEA AGSASETPAG TESPHSSASP CQEHKRGGLS ELKGTPASAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKTYEQVMH YPGGYGSPMP GSLAMGPVTN KAGLDASPLA ADTSYYQGVY SRPIMNSS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Acts synergistically with ONECUT1 to activate transcription of female-specific CYP2C12; the function is inhibited by growth hormone-activated STAT5B. Acts synergistically with HNF4A to activate transcription of APOA1.

Gene References into Functions

MAPK and FoxA2 mediate CS-induced squamous metaplasia. MAPK inhibitors upregulate FoxA2, resulting in a reduction in the degree of squamous metaplasia. PMID:29200841
HNF-1alpha, HNF-4alpha and FOXA2 transcriptional factors are involved in diabetes-induced overexpression of Slc2a2 gene in the liver and kidney. PMID:24157454
Sumoylation increased the transcriptional activity of FOXA2. PMID:23118920
IL-13 down-regulates mucus secretion via STAT6-FOXA2 pathway in vitro. PMID:21269961
Data demonstrate that FoxA2 could dynamically regulate FoxO1 and PDX-1 expression in pancreatic beta-cells treated with DEX. PMID:21385937
increased expression of HNF3beta modestly reduces viral transcription and dramatically inhibits replication in vivo in the HBV transgenic mice. PMID:12438623
Reduced FoxA2 may be important in the suppression of protein C in a rat cecal ligation and puncture (CLP) model of polymicrobial sepsis. PMID:16522789
The results presented here show that Foxa2 and USFs regulate the distal promoter of the rat PC gene in a cell-specific manner. PMID:17408383
The overexpression of the SLC2A2 gene in the kidney of diabetic rats is associated with the transcriptional activity of HNF-1alpha and HNF-3beta. PMID:19433262
Phosphorylation of FoxA2 by DNA-dependent protein kinase modulates its transcriptional activation potential. PMID:19478084

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Subcellular Location

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.

Tissue Specificity

Liver.

Database Links

UNIGENE: Rn.10948

KEGG: rno:25099

STRING: 10116.ENSRNOP00000017742

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