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Recombinant Rat Hepatocyte growth factor receptor (Met), partial

Recombinant Rat Hepatocyte growth factor receptor (Met), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Met

Uniprot NO.

P97523

Alternative Names

MetHepatocyte growth factor receptor; HGF receptor; EC 2.7.10.1; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.

Gene References into Functions

transplantation of c-Met-bone marrow-derived mesenchymal stem cells (BMSCs) ameliorated liver injury with reduced hepatic activity index (HAI) scores, and that the effects of c-Met-BMSCs were more profound than those of control BMSCs. PMID:28679425
Met was strongly expressed in BASCs, which expressed an AT2 cell marker, pro-SP-C, and a club cell marker, CCSP. PMID:26972715
The dynamic expression and localization of different c-MET isoforms in the rat pancreas during different developmental stages indicates that distinct c-MET isoform might be involved in different aspects of pancreatic development PMID:25674220
miR-210 over-expression improves MSC survival under oxidative stress through antioxidation and c-Met pathway activation PMID:25168379
Phosphorylation of Met-Ser985 in hepatocytes plays a regulatory role in Met activation in response to quiescence, injury, and regeneration. PMID:23618918
KRC-408 is a novel therapeutic candidate effective against gastric cancers that overexpress c-Met, inhibiting cell proliferation and angiogenesis. PMID:23348694
c-Met expression in ipsilateral L4-L5 DRGs and within the ipsilateral dorsal horn was found to be significantly up-regulated following sciatic nerve ligation, from day 5 to day 14, with peak levels of expression detected on days 7 and 14. PMID:20814222
This study demonstrates that the sole oncogenic engagement of Met receptor in normal intestinal epithelial cells is sufficient to induce cancerous biological processes that are fundamental to the initiation and progression of colorectal cancers. PMID:20539003
Transfection of phosphatidylethanolamine N-methyltransferase 2 gene causes decreased autophosphorylation of c-Met. PMID:16867273
c-Met-IR in postmitotic neurons as well as in neuroepithelial cells PMID:12106690
HGF receptor, c-met, is end xpressed in testicular and epididymal spermatozoa, exclusively localized on the head in testicular sperm. A different localization in sperm isolated from caput and cauda epididymidis. PMID:12399538
c-Met is involved in the liver invasive phenotype of adult T-cell leukemia PMID:12538467
Cytokines regulate expression of this protein in cultured astrocytes. PMID:12543460
Microarray analysis and RNA silencing link fra-1 to the expression of cd44 and this protein in mesothelioma. PMID:12839939
significant increase in Met docking site activity in both renal medulla and cortex solely following stimulation by ischaemia and repair PMID:12897086
Hgfr signaling mediates the anti-fibrotic action of alitretinoin in glomerular mesangial cells. PMID:16192631
growth factor enriched extracellular milieu and loss of intact liver architecture seems to be accompanied by an up-regulation of c-Met surface level PMID:16465395
Data suggest that intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated Met-beta-catenin dissociation, beta-catenin translocation, activation and mitogenesis. PMID:16952352
Induction (or enhancement) of the endogenous HGF/c-met axis in the kidney is in part responsible for hepatectomy-mediated renal protection in glycerol-induced actue kidney injury. PMID:17940345

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, Tyr protein kinase family

Tissue Specificity

Expressed at highest levels in lung, liver and kidney, also expressed in stomach, intestine, spleen, testis and brain. Not expressed in heart or muscle.

Database Links

UNIGENE: Rn.10617

KEGG: rno:24553

STRING: 10116.ENSRNOP00000009662

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