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Recombinant Rat Heart- and neural crest derivatives-expressed protein 1 (Hand1)

Recombinant Rat Heart- and neural crest derivatives-expressed protein 1 (Hand1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Hand1

Uniprot NO.

P97832

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-216

Target Protein Sequence

MNLVGSYAHH HHHHHSHPPH PMLHEPFLFG PASRCHQERP YFQSWLLSPA DAAPDFPAGG PPPTTAVAAA AYGPDARPSQ SPGRLEALGG RLPRRKGSGP KKERRRTESI NSAFAELREC IPNVPADTKL SKIKTLRLAT SYIAYLMDVL AKDAQAGDPE AFKAELKKTD GGRESKRKRE SPQQHEGLPP ALGPSEKRIK GRTGWPQQVW ALELNQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes.

Gene References into Functions

expressed in the adult rodent heart and is modulated during cardiac hypertrophy PMID:12359233
MEF2/HAND1 interaction results in synergistic activation of MEF2-dependent promoters, and MEF2 binding sites are sufficient to mediate this synergy PMID:16043483
Foxc2 is directly involved in the regulation of Hand1 expression. PMID:19170063

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Subcellular Location

Nucleus, nucleoplasm. Nucleus, nucleolus.

Database Links

UNIGENE: Rn.39340

KEGG: rno:59112

STRING: 10116.ENSRNOP00000003486

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