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Recombinant Rat Guanine nucleotide-binding protein subunit alpha-11 (Gna11)

Recombinant Rat Guanine nucleotide-binding protein subunit alpha-11 (Gna11)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Gna11

Purity

>85% (SDS-PAGE)

Target Names

Gna11

Uniprot NO.

Q9JID2

Alternative Names

Gna11Guanine nucleotide-binding protein subunit alpha-11; G alpha-11; G-protein subunit alpha-11

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-359

Target Protein Sequence

MTLESMIACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAV VRAMDTLKIR YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE SKALFRTIIT YPWFQHSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).

Gene References into Functions

The secretory response to luminal propionate in rat colon is mediated by G-protein on cholesterol-rich membrane microdomains, provably via Galpha(q/11) . PMID:21649864
Levels of Galphaq, Galpha11, phospholipase C (PLC)-beta-1, and PLCbeta-2 proteins are significantly higher in vascular smooth muscle cells exposed to high glucose than in control cells, as determined by western blotting. PMID:20393598
data demonstrate that chronic ethanol feeding suppresses endothelin-1-stimulated glucose uptake and suggest that decreased expression of Galpha11 protein contributes to this response PMID:12684223
supersensitivity of the 5-HT2A receptors, during withdrawal from chronic cocaine, is associated with an increase in membrane-associated Galphaq and Galpha11 proteins PMID:14534355
There is striking specificity in Gq/11-coupled receptor actions on the Ca2+ channels. Differential use of PIP2 signals underlies specificity of Gq/11-coupled receptor actions on the channels. PMID:15574748
Immature frontal lobe Gq/11-coupled receptors elicit activation in a temporally coordinated manner with large calcium transients in most neurons in what appears to be a single explosive burst of activity that propagates as a wave over large distances. PMID:15716410
High glucose increases the expression of Gq/11alpha and PLC-beta proteins and associated signaling in vascular smooth muscle cells. PMID:18820027