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Recombinant Rat Guanine nucleotide-binding protein G (s) subunit alpha isoforms XLas (Gnas), partial

Recombinant Rat Guanine nucleotide-binding protein G (s) subunit alpha isoforms XLas (Gnas), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Gnas

Purity

>85% (SDS-PAGE)

Target Names

Gnas

Uniprot NO.

Q63803

Alternative Names

Gnas; Gnas1; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Adenylate cyclase-stimulating G alpha protein; Extra large alphas protein; XLalphas; G-alpha-8

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-1144

Target Protein Sequence

MGMLNCLHGN NMSGQHDIPP EVGDQPEQEP LEAQGAAAPG AGVGPAEEME TEPSNNEPIP DETDSEVCGP PEDSKSDIQS PSQAFEEVQV GGDYSPPPEE AMPFEIQQPS LGDFWPTLEQ PGPSGTPSGI KAFNPAILEP GTPTGAHPGL GAYSPPPEEA MPFEFNEPAQ EDRCQPPLQV PDLAPGGPEA WVSRALPAEP GNLGFENTGF REDYSPPPEE SVPFQLDGEE FGGDSPPPGL PRVTPQIGIG GEFPTVAVPS TLCLAPAANA PPLWVQGAIG RPFREAVRSP NFAYDISPME ITRPLLEIGR ASTGVDDDTA VNMDSPPIAS DGPPIEVSGA PVKSEHAKRP PLERQAAETG NSPISSTTAE EAKVPSLERG EGSPTQPETV HIKPAPVAES GTDSSKADPD SATHAVLQIG PEEVGGVPTM PTDLPPASED AGPDVRAEPD GGTAPATPAE SEDNREPAAA AAAEPAAEPA AEPAAEPAAE PAAEPAAEAV PDTEAESASG AVPDTQEEPA AAAASATPAE PAARAAPVTP TEPATRAVPS ARAHPAAGAV PGASAMSAAA RAAAARAAYA GPLVWGARSL SATPAARASL PARAAAAARA ASAARAVAAG RSASAAPSRA HLRPPSPEIQ VADPPTPRPA PRPSAWPDKY ERGRSCCRYE AASGICEIES SSDESEEGAT GCFQWLLRRN RRPGQPRSHT VGSNPVRNFF ARAFGSCFGL SECTRSRSLS PGKAKDPMEE RRKQMRKEAM EMREQKRADK KRSKLIDKQL EEEKMDYMCT HRLLLLGAGE SGKSTIVKQM RILHVNGFNG EGGEEDPQAA RSNSDGEKAT KVQDIKNNLK EAIETIVAAM SNLVPPVELA NPENQFRVDY ILSVMNVPNF DFPPEFYEHA KALWEDEGVR ACYERSNEYQ LIDCAQYFLD KIDVIKQADY VPSDQDLPRC RVLTSGIFET KFQVDKVNFH MFDVGGQRDE RRKWIQCFND VTAIIFVVAS SSYNMVIRED NQTNRLQEAL NLFKSIWNNR WLRTISVILF LNKQDLLAEK VLAGKSKIED YFPEFARYTT PEDATPEPGE DPRVTRAKYF IRDEFLRIST ASGDGRHYCY PHFTCAVDTE NIRRVFNDCR DIIQRMHLRQ YELL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms.

Subcellular Location

Cell membrane; Peripheral membrane protein. Apical cell membrane.

Protein Families

G-alpha family, G(s) subfamily

Tissue Specificity

Enriched in neuroendocrine tissues with a particularly high level of expression in pituitary where it is abundant in intermediate and anterior lobes. In adrenal gland, found in central region containing medullary chromaffin cells but not in cortex. In cer

Database Links

UNIGENE: Rn.127731

STRING: 10116.ENSRNOP00000066164

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