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Recombinant Rat Guanine nucleotide-binding protein G (q) subunit alpha (Gnaq)

Recombinant Rat Guanine nucleotide-binding protein G (q) subunit alpha (Gnaq)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Gnaq

Uniprot NO.

P82471

Alternative Names

GnaqGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding protein alpha-q

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-359

Target Protein Sequence

MTLESIMACC LSEEAKEARR INDEIERQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR IIHGSGYSDE DKRGFTKLVY QNIFTAMQAM VRAMDTLKIP YKYEHNKAHA QLVREVDVEK VSAFENPYVD AIKSLWNDPG IQECYDRRRE YQLSDSTKYY LNDLDRVADP SYLPTQQDVL RVRVPTTGII EYPFDLQSVI FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE EKIMYSHLVD YFPEYDGPQR DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).

Gene References into Functions

Enhanced activation of protein kinase C delta (PKCdelta) in vascular smooth muscle cell (VSMC) from hypertensive rats (SHR) increases the expression of G alpha protein q (Gqalpha) and phospholipase C beta1 (PLCbeta1) proteins and results in VSMC hypertrophy. PMID:27379421
Enhanced oxidative stress in VSMCs from SHRs activates c-Src, growth factor receptors and MAPK signaling, contributing to enhanced expression of Gqalpha/PLCbeta1 proteins and VSMC hypertrophy. PMID:26747500
Galphaq protein carboxyl terminus imitation polypeptide GCIP-27 improves cardiac function in chronic heart failure rats. PMID:25822412
Calcium flow through the alpha7 channel and activation of the Galphaq pathway. PMID:24687992
Enhanced the expression of Gqalpha/PLC-beta1 proteins in vascular smooth muscle from 16-wk-old spontaneously hypertensive rats results in VSMC hypertrophy. PMID:24760983
Suggest the involvement of the Gnaq and phosphatidylinositol 3-kinase signaling cascades in mediating melatonin effects in pancreatic alpha-cells. PMID:22672634
Acute beta-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation PMID:23161540
These studies show that caveolae play a direct and active role in regulating basal Ca(2+) activity in cardiomyocytes. PMID:21463572
Pre-treatment with propofol can reduce the concentration of Gq/11 protein in kidney tissue during acute respiratory distress syndrome. PMID:17166350
increased levels in vascular smooth muscle cells exposed to high glucose and in aortic vascular smooth muscle cells from diabetic rats PMID:20691780
C-terminal deletion of mGlu(1) receptor selectively abolishes Galpha(q/11) coupling. PMID:19879871
9 aa in the N terminus of RGS8 contribute to the function to inhibit Gq-coupled signaling in a receptor type-specific manner and the regulatory function of RGS8S is especially diminished on Gq-coupled responses PMID:12110731
an Akt-mediated cell survival pathway is compromised by the diminished availability of PIP2 elicited by pathological levels of Gq activity in cardiomyocytes PMID:12900409
Results suggest a potential pathophysiological role of loss of fine tuning due to selective RGS2 down-regulation in G(q/11)-mediated remodeling in hypertrophic cardiomyocytes. PMID:16380388
increased Galphaq activity can provide anti-apoptotic signals by eliciting EGFR phosphorylation and subsequent Akt activation PMID:16466740
Inhibition of rat granulosa cell differentiation by overexpression of Galphaq. PMID:18401763
The carboxyl-terminus of a synthetic G alpha q peptide effectively attenuates left ventricular remodelling in spontaneously hypertensive rats; the anti-remodelling effect may not be dependent entirely on decreases in blood pressure. PMID:18518877
These findings suggest that G(q/11)-coupled receptors function as sensors of membrane stretch in VSM cells. PMID:18987636