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Recombinant Rat Growth factor receptor-bound protein 2 (Grb2)

Recombinant Rat Growth factor receptor-bound protein 2 (Grb2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Grb2

Uniprot NO.

P62994

Alternative Names

Grb2; AshGrowth factor receptor-bound protein 2; Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-217

Target Protein Sequence

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

Gene References into Functions

GRB2 plays an important role in CCl4-induced hepatic fibrosis by regulating hepatic stellate cell function, and up-regulation of GRB2 induced by HMGB1 is mediated via the PI3K/AKT pathway. PMID:28618656
Growth factor receptor-bound 2 is a direct target of miR-96, which is a negative regulator of cardiac hypertrophy. PMID:26782545
Study confirmed that miR-19b provided a novel mechanism for regulating liver stellate cells proliferation through the targeting of GRB2. PMID:25650006
Free fatty acids may inhibit insulin activity in rat islet cells through up-regulating the expression of cPKCalpha or down-regulating the expression of Grb2 and ERK2. PMID:21180072
signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain PMID:12084708
The Grb2 signal pathway is critical in angiotensin II-dependent smooth muscle vascular endothelial cell division. PMID:12837289
Results describe the regulation of growth factor receptor bound 2 (Grb2) in response to electroconvulsive seizure. PMID:15469895
These results suggest that DISC1 is required for NT-3-induced axon elongation and ERK activation at the distal part of axons by recruiting Grb2 to axonal tips. PMID:17202467