Recombinant Rat Gelsolin (Gsn)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Gsn

Purity

>85% (SDS-PAGE)

Target Names

Gsn

Uniprot NO.

Q68FP1

Alternative Names

GsnGelsolin; Actin-depolymerizing factor; ADF; Brevin

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

26-780

Target Protein Sequence

ATASR GRAQERAPQS RVSETRPSTM VVEHPEFLKA GKEPGLQIWR VEKFDLVPVP PNLYGDFFTG DAYVILKTVQ LRNGNLQYDL HYWLGNECSQ DESGAAAIFT VQLDDYLNGR AVQHREVQGF ESSTFQGYFK SGLKYKKGGV ASGFKHVVPN EVVVQRLFQV KGRRVVRATE VPVSWDSFNN GDCFILDLGN NIYQWCGSGS NKFERLKATQ VSKGIRDNER SGRAQVHVSE EGSEPEAMLQ VLGPKPDLPQ GTEDTAKEDA ANRRLAKLYK VSNSGGSMSV SLVADENPFA QSALRSEDCF ILDHGRDGKI FVWKGKQANM DERKAALKTA SDFISKMQYP RQTQVSVLPE GGETPLFKQF FKNWRDPDQT DGPGLSYLSS HIANVERVPF DAATLHTSTA MAAQHGMDDD GTGQKQIWRI EGSNKVLVDP ATYGQFYGGD SYIILYNYRH GGRQGQIIYN WQGAQSTQDE VAASAILTAQ LDEELGGTPV QSRVVQGKEP AHLMSLFGGK PMIIYKGGTS RDGGQTTPAS TRLFQVRASS SGATRAVEVM PKAGALNSND AFVLKTPSAA YLWVGTGASD AEKTGALELL KVLRAQHVQV EEGSEPDGFW EALGGKTAYR TSPRLKDKKM DAHPPRLFAC SNRIGRFVIE EVPGELMQED LATDDVMLLD TWDQVFVWVG KDSQEEEKTE ALTSAKRYIE TDPANRDRRT PITVVRQGFE PPSFVGWFLG WDDDYWSVDP LDRALAELAA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

Gene References into Functions

Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS). PMID:28193690
These findings suggested a potential role of GSN in the pathophysiology of the brain at the early stage of subarachnoid hemorrhage. PMID:25744577
It was concluded that cytoskeletal effects of Cd in mesangial cells are partially mediated by Cd-dependent activation of CaMK-IIdelta, binding of CaMK-IIdelta and gelsolin to actin filaments, and cleavage of gelsolin. PMID:22553113
Gelsolin is a component of Sertoli cell intercellular adhesion complexes, and plays a role in the disassembly of actin filaments and in the resulting release of sperm. PMID:11861757
observed ubiquitous increase of gelsolin in senescent states of cells and tissues, and increased sensitivity to apoptosis-induction by gelsolin down-regulation, suggests that it would be partly responsible for age-related apoptosis resistance. PMID:14652020
gelsolin modulates the actin cytoskeleton and regulates vacuolar H+-ATPase recycling PMID:15591047
Results suggest that the spatiotemporal upregulation of gelsolin in the hippocampus is induced by entorhinal deafferentation. PMID:16261560
Gelsolin is found at high levels (comparable to plasma) in mesenteric lymph. Following hemorrhagic shock, gelsolin levels decrease significantly, possibly due to consumption by the actin scavenging system. PMID:17950082
This report indicates that structural differences between plasma and cytoplasmic gelsolin do not play a key role in their complex formation with Abeta. PMID:18287947