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Recombinant Rat Gamma-aminobutyric acid receptor-associated protein (Gabarap)

Recombinant Rat Gamma-aminobutyric acid receptor-associated protein (Gabarap)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Gabarap

Uniprot NO.

P60517

Alternative Names

Gabarap; Gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-116

Target Protein Sequence

MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activition of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination a nd degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation. Involved in apoptosis.

Gene References into Functions

Macroautophagic sequestration does not require the LC3 subfamily but the GABARAP subfamily is essential. PMID:25684710
These results support the regulatory role of Bcl-2 in autophagy and define GABARAP as a novel interaction partner involved in this intricate connection. PMID:24240096
GABARAP and AT(1)R interact through discrete domains and this association regulates the cell-surface accumulation and, consequently, ligand-induced function of the receptor. PMID:19766149
The results of this study show that GABARAP has a functional effect on the trafficking of GABA(A) receptors and provide evidence for the role of GABARAP in transporting GABA(A) receptors to the plasma membrane in neurons. PMID:15601949
Coexpression of GABARAP increases the steady-state expression of GABA-A receptors at the cell surface. Coexpression of GABARAP increases GABA currents by 2- to 3-fold. PMID:15814572
Carboxyl-terminal processing of GABARAP is essential for the localization of GABARAP and its functions as a trafficking protein. PMID:17581952