Recombinant Rat Fibroblast growth factor 7 (Fgf7)

1. The findings of the present study indicated that KGF, CTGF and TGF-beta have biological roles in progression of CsA- and PNT- induced GO. KGF plays a greater role in CsA- induced GO than in PNT- induced GO. Meanwhile, CTGF and TGF-beta play a role in PNT- induced GO greater than in CsA- induced GO. PMID:26894526
2. These data demonstrate that administration of MSCs to the inflammation-insulted AT-II cells may ameliorate the impairments through a KGF-dependent PI3K/AKT/mTOR signaling pathway. PMID:27035760
3. The primary role of both KGF1 and FGF2 appeared to be in the proliferation and migration of keratinocytes PMID:21136143
4. KGF may have a role in ameliorating radiation-induced pulmonary injury in rats PMID:21436609
5. KGF promotes preadipocyte proliferation by an autocrine mechanism that involves activation of the PI3K/Akt signaling pathway PMID:20069574
6. Keratinocyte growth factor may promote alveolar epithelial repair through several mechanisms involved in cell migration PMID:12581741
7. Decreased gene expression of FGF-7 in the rat hypoplastic lung suggests that pulmonary hypoplasia in nitrofen-induced congenital diaphragmatic hernia rat may be caused by reduced synthesis of FGF-7 during lung morphogenesis. PMID:12861530
8. KGF stimulates lipogenesis in alveolar type II cells by a coordinated expression of lipogenic enzymes and transport proteins regulated by C/EBP isoforms and SREBP-1c PMID:12865412
9. stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3 PMID:14506240
10. Exogenous administered KGF cDNA causes increases in IGF-I, IGF-BP3, FGF, and collagen IV and decreases TGF-beta concentration. KGF gene transfer accelerates wound healing without causing an increase in collagen I or III. PMID:17292422
11. KGF improves alterations of lung permeability and bronchial epithelium in allergic rats PMID:17392324
12. retention of the AT2 cell phenotype by KGF involves c-Jun and suggest that activation of c-Jun kinase may be an important determinant of maintenance of AT2 cell phenotype PMID:17872496
13. FGF-7, most likely through its effect on the vascular bed, is required for normal early postnatal alveolar formation from secondary crests. PMID:18091341
14. the effects of KGF on duct cell proliferation are mediated by the MEK-ERK1/2 pathway, while the KGF-induced cell differentiation is mediated by the PI3K/AKT pathway PMID:19266047

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UNIGENE: Rn.98842

KEGG: rno:29348

STRING: 10116.ENSRNOP00000012700