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Recombinant Rat Fibroblast growth factor 16 (Fgf16)

Recombinant Rat Fibroblast growth factor 16 (Fgf16)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Fgf16

Uniprot NO.

O54769

Alternative Names

Fgf16Fibroblast growth factor 16; FGF-16

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-207

Target Protein Sequence

MAEVGGVFAS LDWDLQGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER GELFGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS RDLFRYR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

Gene References into Functions

Cardiac Fgf-16 expression supports cardiomyocyte survival and increases resistance to doxorubicin cytotoxicity. PMID:30230915
FGF-16 employs a unique bipartite signal sequence that is not cleaved, although it shares the same secretory machinery used by secreted proteins with cleavable signal sequences. PMID:12851399
Expression and release of FGF-16 in the neonatal myocardium interfere with cardiac myocyte proliferative potential by altering the local signaling environment via modulation of PKC activation and cell cycle-related gene expression. PMID:18337564

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Subcellular Location

Secreted.

Protein Families

Heparin-binding growth factors family

Tissue Specificity

In adult, predominantly expressed in heart, in the cardiac myocytes. Not detected in brain, lung, liver, kidney and white adipose tissue. In embryos, predominantly expressed in the brown adipose tissue.

Database Links

UNIGENE: Rn.44348

KEGG: rno:60464

STRING: 10116.ENSRNOP00000003463

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