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Recombinant Rat Fatty acid-binding protein, epidermal (Fabp5)

Recombinant Rat Fatty acid-binding protein, epidermal (Fabp5)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Fabp5

Uniprot NO.

P55053

Alternative Names

Fabp5Fatty acid-binding protein 5; Cutaneous fatty acid-binding protein; C-FABP; DA11; Epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein; epidermal

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

2-135

Target Protein Sequence

ASLKDLEGK WRLVESHGFE DYMKELGVGL ALRKMGAMAK PDCIITLDGN NLTVKTESTV KTTVFSCTLG EKFDETTADG RKTETVCTFT DGALVQHQKW EGKESTITRK LKDGKMVVEC VMNNAICTRV YEKVQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation.

Gene References into Functions

FABP5 is upregulated in alveolar macrophages during severe inflammation. PMID:20854474
epithelial fatty acid-binding protein (Fabp5, E_FABP)participates in leukotriene biosynthesis that permits of leukotriene A4 to be available for further enzymatic processing in various cellular regions. PMID:14676186
C-FABP may play a significant role in regulating adipocyte function in response to changes in nutritional conditions. PMID:17898460
These findings are consistent with the scenario that neurite extension of differentiating PC12 cells, including further stimulation by DHA and EPA, requires sufficient cellular levels of E-FABP. PMID:18513372