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Recombinant Rat Eukaryotic translation initiation factor 4E-binding protein 1 (Eif4ebp1)

Recombinant Rat Eukaryotic translation initiation factor 4E-binding protein 1 (Eif4ebp1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Eif4ebp1

Purity

>85% (SDS-PAGE)

Target Names

Eif4ebp1

Uniprot NO.

Q62622

Alternative Names

Eif4ebp1Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

2-117

Target Protein Sequence

SAGSSCSQT PSRAIPTRRV ALGDGVQLPP GDYSTTPGGT LFSTTPGGTR IIYDRKFLME CRNSPVAKTP PKDLPTIPGV TSPTSDEPPM QASQSHLHSS PEDKRAGGEE SQFEMDI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Gene References into Functions

FGF signaling differentially impacts protein synthesis through either stimulation or repression, in a cell-type-dependent manner, with 4E-BP1 being a key player. PMID:27313212
Phosphorylation of 4EBP1 is suppressed following treatment with everolimus in combination with radiation. PMID:25200811
peptides that encompass the Raptor cross-linking region of 4E-BP1 inhibit cross-linking and interaction of 4E-BP1 with Raptor. PMID:24403073
New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress. PMID:20736160
eIF4E is rate-limiting for cell cycle progression before it regulates cell growth PMID:14607835
phosphorylation of 4E-BP1 is regulated by L-arginine through the mTOR signaling pathway PMID:15010853
eukaryotic initiation factor 4E-binding protein 1 gene transcription is regulated by polyamines PMID:15351722
Lipopolysaccharide did not prevent the ability of pharmacological levels of IGF-I to phosphorylate 4E-BP1, S6K1, mTOR or alter the availability of eIF4E. PMID:15389631
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on 4E-BP1 PMID:15767663
The oxidative stress generated by H2O2 in NGF-differentiated PC12 cells, 4E-BP1 and eIF4E phosphorylated levels decrease significantly, and an enhancement of the association of 4E-BP1 to eIF4E, which in turn decreases eIF4F formation is observed. PMID:15907373
AMPK activation attenuates 4E-BP1 response to high-frequency electrically stimulated skeletal muscle contractions. PMID:18187610
eIF4G integrity and hyperphosphorylated 4E-BP1 are needed to ensure appropriate translation in neurons PMID:18215131