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Recombinant Rat Endothelial transcription factor GATA-2 (Gata2)

Recombinant Rat Endothelial transcription factor GATA-2 (Gata2)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Gata2

Purity

>85% (SDS-PAGE)

Target Names

Gata2

Uniprot NO.

Q924Y4

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-480

Target Protein Sequence

MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASPSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP ATHHPIPTYP SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection.

Gene References into Functions

The trans-repressive action of GATA2 on Gnrhr promoter activity is likely balanced or even hindered by trans-activating effects of LIM homeodomain proteins. PMID:23211524
GATA2 stimulates transcriptional activity of the luteinizing hormone beta gene promoter PMID:21571865
hese findings indicate that Gata2 plays a required role in the transition of postmitotic neuronal precursor cells of the retinorecipient layers of the superior colliculus into mature neurons PMID:21430145
There may be a regulatory role played by the Gata-3,-2 transcription factors in prestin expression. PMID:20006695
down regulation of GATA-2 gene correlates with reduced phagocytic acitivity of alveolar macrophages in P. carinii infected host PMID:11906041
GATA-2 plays an important role in the regulation of phagocytosis in alveolar macrophages during Pneumocystis carinii infection PMID:12933836
GATA2 has a role in the transcriptional up-regulation of endothelial cell matrix metalloproteinase-2 in response to extracellular cues PMID:14512418
clenbuterol may act through upregulating the GATA-2 transcription factor and implicate certain PKC isoforms in the drug-induced regulation of skeletal muscle development. PMID:17948249
These results demonstrate that GATA-2 is involved in multiple promoter regions to activate the specific expression of the rPL-I gene in placental tissue. PMID:19357811