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Recombinant Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (Enpp3), partial

Recombinant Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (Enpp3), partial

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Product Details

Purity

>85% (SDS-PAGE)

Target Names

Enpp3

Uniprot NO.

P97675

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity.

Gene References into Functions

ecto-nucleotide pyrophosphatase/phosphodiesterase 1 and 3 are expressed on podocytes, but changes in expression of these enzymes are most likely not involved in etiology of insulin resistance in podocytes. PMID:22086174
Lubrol resistance is an intrinsic property of NPP3 but not NPP1, which is acquired early during the biosynthetic process irrespective of its final destination, and depends on positively charged residues in its cytoplasmic tail. PMID:17311850
The expression of NPP3 decreased during the aging mainly on cerebellum, hippocampus, and olfactory bulb. PMID:18565716

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Subcellular Location

Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted.

Protein Families

Nucleotide pyrophosphatase/phosphodiesterase family

Tissue Specificity

Detected in intestinal epithelium and liver (at protein level).

Database Links

UNIGENE: Rn.44

KEGG: rno:54410

STRING: 10116.ENSRNOP00000018695

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