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Recombinant Rat ERBB receptor feedback inhibitor 1 (Errfi1)

Recombinant Rat ERBB receptor feedback inhibitor 1 (Errfi1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Errfi1

Uniprot NO.

P05432

Alternative Names

Errfi1; 33; Mig6ERBB receptor feedback inhibitor 1; Gene 33 polypeptide; Mitogen-inducible gene 6 protein homolog; MIG-6; Receptor-associated late transducer; RALT

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

2-459

Target Protein Sequence

STAGVAAQD IRVPLKTGFL HNGQALGNMK TCWGSRNEFE KNFLNIDPIT MAYNLNSPAP EHLTTLGCAS PSAPGSGHFF AERGPSPKSS LPPLVIPPSE SSGQREEDQV LCGFKKLSVN GVCASTPPLT PIQSCSSPFP CAAPCDRSSR PLPPLPISED PSLDEADCEV EFLTSADTDF LLEDCVPSDF KYDVPGRRSF RGCGQINYAY FDSPTVSVAD LSCASDQNRV VPDPNPPPPQ SHRRLRRSHS GPAGSFNKPA IRISSCTHRA SPSSDEDKPE IPPRVPIPPR PAKPDYRRWS AEVTSNTYSD EDRPPKVPPR EPLSRSNSRT PSPKSLPSYL NGVMPPTQSF APDPKYVSSK ALQRQSSEGS AKAPCILPII ENGKKVSSTH YYLLPERPPY LDKYEKYFRE AEEANPSTQI QPLPAACGMV SATDKLASRM KMDVGGHGKR KHLSYVVSP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.

Gene References into Functions

Mig6 functions as a molecular brake for beta-cell proliferation during glucocorticoid treatment in beta-cells, and thus, Mig6 may be a novel target for preventing glucocorticoid-induced impairments in functional beta-cell mass. PMID:23384834
RALT drives endocytosis and degradation of kinase-suppressed EGFR molecules PMID:20421427
Gene 33 is a physiological feedback inhibitor of the EGFR, functioning to inhibit EGFR phosphorylation and all events induced by EGFR activation PMID:15556944
The abundance of Errfi1 in the pineal gland exhibits a >10-fold increase at night, apparently under adrenergic cyclic AMP control. PMID:19103603
MIG-6/RALT is a transcriptionally controlled inhibitor of mitogenic and transforming signals generated by the ErbB-2 oncogene. MIG-6/RALT forms a physical complex with activated ErbB-2 and co-localizes with ErbB-2 in living cells. PMID:11003669
Loss of MIG-6/RALT mRNA and protein expression occurs in ERBB2-amplified breast cancer cell lines and enhances ERBB2 oncogenic signalling. PMID:15856022
ERK activity is necessary and sufficient to induce Gene33/RALT expression. Neutralization of RALT function inhibits ErbB-2 mitogenic signalling. Hence, RAS-ERK signals control the activity of a negative feed-back loop acting on ErbB-2. PMID:12226756
Gene33/RALT inhibits mitogenic signals generated by EGFR, ErbB-4 and ErbB-2.ErbB-3 dimers, but does not affect PDGF, bFGF and IL-3 dependent cell proliferation. Hence, RALT is a pan-ErbB inhibitor. PMID:12833145