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Recombinant Rat Double-strand break repair protein MRE11A (Mre11a)

Recombinant Rat Double-strand break repair protein MRE11A (Mre11a)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Mre11a

Purity

>85% (SDS-PAGE)

Target Names

Mre11

Uniprot NO.

Q9JIM0

Alternative Names

Mre11; Mre11a; Double-strand break repair protein MRE11; EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

2-706

Target Protein Sequence

SPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEIISDQSVN FGFSKFPWVN YRDGNLNISI PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL VIWGHEHECK IGPTRNEQQL FYVSQPGSSV VTALSPGETV KKHVGLLRVK GRKMNMQKLP LRTVRQFFME DVVLANHPSL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPEK PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGKLIIK PASEGTTLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSENAASA FSADDLSFDI TEQTADDSDD SQSAVPSRGR GRGRGRRGGR GQSTAPRGGS QRGRDTGLGI STRGRSSKAT ASTSRNMSII DAFRSTRQQP SRNVATKNYS ETIEVDESDD DDSFPTSSRA DQRWSGTAPS KRMSQSQTAK GVDFESDEDD DDDPFMSGSC PRRNRR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Subcellular Location

Nucleus. Chromosome, telomere. Chromosome.

Protein Families

MRE11/RAD32 family

Database Links

UNIGENE: Rn.209040

KEGG: rno:64046

STRING: 10116.ENSRNOP00000012940

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