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Recombinant Rat Diacylglycerol kinase gamma (Dgkg)

Recombinant Rat Diacylglycerol kinase gamma (Dgkg)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Dgkg

Uniprot NO.

P49620

Alternative Names

Dgkg; Dagk3Diacylglycerol kinase gamma; DAG kinase gamma; EC 2.7.1.107; 88 kDa diacylglycerol kinase; Diglyceride kinase gamma; DGK-gamma

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-788

Target Protein Sequence

MSDGQWVCLS SEEFDQLQKY SEYSSKKIKD VLAEFNEGGS LKQYDPHKPI SYDVFKLFMR AYLEVDLPQP LSTNLFLAFS QKPRQETPDH PKEGASSSEP NVSDSNAEST AKADAACAPD TESKPIKTQV PSEELEAAAP WGEPNAPASS SDAPIVYLKD VVCYLSLMET GRPQDKLEFM FRLYDSDENE LLDQAELDQI VSQMLHVAQY LEWDPTELRP ILKEMLQGMD YNKDGFVSLE EWVSGGMTTI PLLVLLGMDD SASKGDGRHA WTLKHFKKPT YCNFCHIMLM GVRKQGLCCI YCKYAVHQRC VSNSIPGCVK TYSKAKRSGE VMQHAWVEGN SSVKCDRCHK SIKCYQSVTA RHCVWCRMTF HRKCELSTAC DGGELKDHIL LPTSIYPVTR DRQAGKSDSG AAAKGELVMQ YKIIPSPGTH PLLVLVNPKS GGRQGERILQ KFHYLLNPKQ VFNLDKGGPT PGLNFFQDTP DFRVLACGGD GTVGWILDCI DKANFTKHPP VAVLPLGTGN DLARCLRWGG GYEGGSLTKI LKEIEQSPLV MLDRWYLEVM PREEVENGDQ VPYNIMNNYF SIGVDASIAH RFHVMREKHP EKFNSRMKNK LWYFEFGTSE TFAATCKKLH DHIELECDGV EVDLSNIFLE GIAILNIPSM YGGTNLWGET KKNRAVIRES RKSVTDPKEL KCCVQDLSDQ LLEVVGLEGA MEMGQIYTGL KSAGRRLAQC SSVTIRTKKL LPMQVDGEPW MQPPCMIKIT HKNQAPMMMG PPQKSSFFSL RRKSRSKD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has no apparent specificity with regard to the acyl compositions of diacylglycerol. Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination.

Gene References into Functions

Knockdown of Dgkg, but not DGK-alpha, inhibited degranulation in mast cells. PMID:24513282
In brain, DGKgamma showed sustained expression throughout the postnatal developmental periods. And In the hippocampal pyramidal cell, Dgkg localized in the cytosol. PMID:16019106
localization and activation of the functionally correlated kinases, gammaPKC and DGKgamma, are spatio-temporally orchestrated by their direct association and phosphorylation, contributing to subtype-specific regulation of DGKgamma and DAG signaling PMID:16905533

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Subcellular Location

Membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.

Protein Families

Eukaryotic diacylglycerol kinase family

Tissue Specificity

Expressed specifically in brain. Highly expressed in cerebellar Purkinje cells (at protein level).

Database Links

UNIGENE: Rn.10544

KEGG: rno:25666

STRING: 10116.ENSRNOP00000002452

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