Recombinant Rat D site-binding protein (Dbp)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Dbp

Uniprot NO.

P16443

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-325

Target Protein Sequence

MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK EKERKATLPS APVPGPVLET AGPADAPTGA VSGGGSPRGR SGPVAGPSLF APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGLSP APSPARTPAP SPGPGSCSSS SPRSSPGHAP ARATLGAAGG HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKVQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE VVAVRQELSH YRAVLSRYQA QHGTL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

Gene References into Functions

Data show that the expression of clock genes Per2, Bmal1 and Dbp follow a diurnal rhythm in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleu but the phase and amplitude of the rhythms of each gene vary across the 3 regions. PMID:25068868
The localization and diurnal variation of BMAL1, DBP and PER2 are changed in remnant kidney of 5/6 nephrectomy rats and are involved in diurnal rhythm of renal function. PMID:23738784
Data show that knockdown of DBP, D-box positive regulator, led to a short-period phenotype, and overexpression of DBP produced a long-period rhythm, while knockdown and overexpression of E4BP4, D-box negative regulator, had the opposite effect of DBP. PMID:21635892
Dbp and estrogen regulate the expression of Kiss1 in the anteroventral periventricular nucleus PMID:21458520
natural body temperature rhythms can affect circadian gene expression PMID:12372249
per2 and dbp expression in the heart and liver is increased in streptozotocin-induced diabetes PMID:15792371
Data suggest that DBP may represent an important transcriptional link between glucagon-like peptide-1 receptor activation and neuroplasticity in the hippocampus. PMID:16257226
DBP has the ability to bind the DBP binding site located in the distal promoter region of the PEPT1 gene & induce the transcriptional activity. These findings indicate that DBP plays pivotal roles in the circadiran oscillation of PEPT1. PMID:18583459
The rhythmic mRNA expression of clock genes (Clock, Bmal1, Cry1, and Dbp) is not attenuated in the liver and visceral adipose tissues of Goto-Kakizaki rats, a model of nonobese, type 2 diabetes, as compared to control Wistar rats. PMID:19387896