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Recombinant Rat Cyclin-dependent kinase 4 inhibitor B (Cdkn2b)

Recombinant Rat Cyclin-dependent kinase 4 inhibitor B (Cdkn2b)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cdkn2b

Uniprot NO.

P55272

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-130

Target Protein Sequence

MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV CDAWGRLPVD LAEEQGHRDI ARYLHAATGD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Gene References into Functions

The P15 gene mutation was significantly correlated with osteosarcoma formation and metastasis. PMID:26921270
Oviductus Ranae promotes the expression of P15 through a feedback mechanism to prevent excessive proliferation of hepatocytes in aged male rats. PMID:20501390
Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats. PMID:21147108
Northern analysis confirmed upregulation of PAI-1, P2X4, and P15INK4B in cultured alveolar epithelial type I cells (AT1); in whole lung, all three proteins were detected in alveolar epithelium in a location consistent with expression in AT1 cells PMID:12600825

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Protein Families

CDKN2 cyclin-dependent kinase inhibitor family

Tissue Specificity

Expression abundant in lung, less abundant in testis, barely detectable in liver, and not detectable in neonatal kidney, adult kidney, brain, heart, or spleen.

Database Links

UNIGENE: Rn.105626

KEGG: rno:25164

STRING: 10116.ENSRNOP00000008898

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