Recombinant Rat Contactin-1 (Cntn1), partial

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Source
Conjugate
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Target Background

Product Details

Abbreviation

Cntn1

Purity

>85% (SDS-PAGE)

Target Names

Cntn1

Uniprot NO.

Q63198

Alternative Names

Cntn1Contactin-1; Neural cell surface protein F3

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

21-1001

Target Protein Sequence

EFTWHRRYGH GVSEEDKGFG PIFEEQPINT IYPEESLEGK VSLNCRARAS PFPVYKWRMN NGDVDLTNDR YSMVGGNLVI NNPDKQKDAG IYYCLASNNY GMVRSTEATL SFGYLDPFPP EDRPEVKVKE GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF ITMDKRRFVS QTNGNLYIAN VESSDRGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY PADIVVQFKD IYTMMGQNVT LECFALGNPV PDIRWRKVLE PMPTTAEIST SGAVLKIFNI QLEDEGLYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW PCVATGKPIP TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENAYGTI YANAELKILA LAPTFEMNPM KKKILAAKGG RVIIECKPKA APKPKFSWSK GTEWLVNSSR ILIWEDGSLE INNITRNDGG IYTCFAENNR GKANSTGTLV ITNPTRIILA PINADITVGE NATMQCAASF DPSLDLTFVW SFNGYVIDFN KEITNIHYQR NFMLDANGEL LIRNAQLKHA GRYTCTAQTI VDNSSASADL VVRGPPGPPG GLRIEDIRAT SVALTWSRGS DNHSPISKYT IQTKTILSDD WKDAKTDPPI IEGNMESAKA VDLIPWMEYE FRVVATNTLG TGEPSIPSNR IKTDGAAPNV APSDVGGGGG TNRELTITWA PLSREYHYGN NFGYIVAFKP FDGEEWKKVT VTNPDTGRYV HKDETMTPST AFQVKVKAFN NKGDGPYSLI AVINSAQDAP SEAPTEVGVK VLSSSEISVH WKHVLEKIVE SYQIRYWAGH DKEAAAHRVQ VTSQEYSARL ENLLPDTQYF IEVGACNSAG CGPSSDVIET FTRKAPPSQP PRIISSVRSG SRYIITWDHV VALSNESTVT GYKILYRPDG QHDGKLFSTH KHSIEVPIPR DGEYVVEVRA HSDGGDGVVS QVKISGVSTL S
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.

Gene References into Functions

Expression of alternatively spliced FnIII domains of tenascin-C is differentially regulated after brain injury, with strong increases of domains B and D that may well influence axonal regeneration and repair processes in the damaged nervous system. PMID:20451518
Data show that the rat F3/contactin gene differs from the mouse gene in that it contains two additional untranslated exons that are alternatively spliced and lacks the homologue mouse untranslated exon 0. PMID:15967539

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Families

Immunoglobulin superfamily, Contactin family

Tissue Specificity

Expressed by neurons, oligodendrocytes and their progenitors (at protein level). Myelination regulates the expression being downregulated when neurons are in contact with Schwann cells.

Database Links

UNIGENE: Rn.143291

KEGG: rno:117258

STRING: 10116.ENSRNOP00000006219

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