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Recombinant Rat Complement component C6 (C6), partial

Recombinant Rat Complement component C6 (C6), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

Q811M5

Alternative Names

C6Complement component C6

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

22-934

Target Protein Sequence

CFCDHYPWT HWSSCSKSCN SGTQSRQRQI VVNDYYRDNS CDQLCTKQET RQCNVETCPI NCVLGDYGTW SDCDPCIRKQ VKVRSVLRPS QFGGQPCTEP LVTFQPCVPS ELCKIEETDC KNKFLCDSGR CIPSKLKCNG ENDCGDNSDE RNCGRTKPVC SRTYTPIPSV QLMGAGFHFL AGEPRGDVPD NSFTGGICKS VRSSRTSNPH RVPANLENVN FEVQTIEDDL KTDFYKDLAT IGKNKNEDRS LSGEKKDSFY VPIFYSSKKS ENFQRNSGFK NAIEASHKKD SSFVRIHKVI KVLNFTMKTT DLQLSDVFLK ALIHLPLEYN FALYSRIFDD FGTHYFTSGS LGGKYDLLYQ FSRQELQNSG LTEEETRNCV RYETKKRFLF FTKTYKEDRC TTNRLSEKYK GSFLQGSEKS ISLVQGGRSQ QAAALAWEKG SSGPEANVFS EWLESVKENP AVVDYELAPI IDLVRNIPCA VTKRNNLRKA LQEYAAKFDP CQCAPCPNNG RPRLSGTECL CVCQSGTYGE NCEKRSPDYK SNAVDGNWGC WSSWSACNAA YRRSRSRECN NPEPQRGGQR CEGKHWQEED CTFSIMEKVG QPCISDDEEI KEVDLAEPEA DSGCPQPPLP ENAFVWNEKK LYSVGEEVEI SCLTGFKAVG YQYFRCLPDR TWRQGDVECQ RTECLKPVVQ DVLTISPFQS VYKIGESIEL TCPRGFVVAG PSRYTCKGDS WTPPIPNSLS CEKDILTKSK GLCQPGQKQS GSECVCMSPE EDCSSYSEDL CIFDEGSSQY FTSSACKFLA EKCLNSNQFH FVHAGSCQEG PQLEWGLERL KLAMKSTKRV PCGYDTCYDW EKCSAHTSNC VCLLPPQCPK DENQLHCVKM GSSMRGKTVN ICTLGAVRCA NRKVEILNPG RCLD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

Gene References into Functions

Findings suggest that C6 deficiency by itself does not alter the regrowth capacity of the peripheral nerve after crush injury. PMID:25011063
The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury. PMID:18178252
C6 deficiency did not lead to neuroprotection after status epilepticus PMID:21575686
The membrane attack complex of complement induces caspase activation and apoptosis. PMID:11870622
Lung allografts from C6-deficient donors to C6(-) recipients survive 13-17 days, whereas allografts from C6-sufficient donors to C6(+) recipients are rejected with intense vascular infiltration and diffuse alveolar hemorrhage 7 days posttransplant. PMID:12370401
This study demonstrates that complement component 6 is not essential for the development of proteinuria in passive Heymann nephritis. PMID:17579035
essential in the mechanism of hepatic ischemia/reperfusion injury PMID:18668646
Pathology showed improved nerve regeneration in tibials of C6 deficient animals compared to wildtypes. PMID:19833392