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Recombinant Rat Collagen alpha-1 (II) chain (Col2a1), partial

Recombinant Rat Collagen alpha-1 (II) chain (Col2a1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Col2a1

Uniprot NO.

P05539

Alternative Names

Col2a1Collagen alpha-1(II) chain; Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

114-1173

Target Protein Sequence

QMAGGFD EKAGGAQMGV MQGPMGPMGP RGPPGPAGAP GPQGFQGNPG EPGEPGVSGP IGPRGPPGPA GKPGDDGEAG KPGKAGERGL PGPQGARGFP GTPGLPGVKG HRGYPGLDGA KGEAGAPGVK GESGSPGENG SPGPMGPRGL PGERGRTGPA GAAGARGNDG QPGPAGPPGP VGPAGGPGFL GAPGAKGEAG PTGARGPEGA QGSRGEPGNP GSPGPAGASG NPGTDGIPGA KGSAGAPGIA GAPGFPGPRG PPGPQGATGP LGPKGQTGEP GIAGFKGEQG PKGETGPAGP QGAPGPAGEE GKRGARGEPG GAGPIGPPGE RGAPGNRGFP GQDGLAGPKG APGERGPSGL AGPKGANGDP GRPGEPGLPG ARGLTGRPGD AGPQGKVGPS GAPGEDGRPG PPGPQGARGQ PGVMGFPGPK GANGEPGKAG EKGLAGAPGL RGLPGKDGET GAAGPPGPSG PAGERGEQGA PGPSGFQGLP GPPGPPGEGG KQGDQGIPGE AGAPGLVGPR GERGFPGERG SPGAQGLQGP RGLPGTPGTD GPKGAAGPDG PPGAQGPPGL QGMPGERGAA GIAGPKGDRG DVGEKGPEGA PGKDGGRGLT GPIGPPGPAG ANGEKGEVGP PGPSGSTGAR GAPGERGETG PPGPAGFAGP PGADGQPGAK GDQGEAGQKG DAGAPGPQGP SGAPGPQGPT GVTGPKGARG AQGPPGATGF PGAAGRVGPP GSNGNPGPAG PPGPAGKDGP KGARGDTGAP GRAGDPGLQG PAGAPGEKGE PGDDGPSGSD GPPGPQGLAG QRGIVGLPGQ RGERGFPGLP GPSGEPGKQG APGASGDRGP PGPVGPPGLT GPAGEPGREG SPGADGPPGR DGAAGVKGDR GETGALGAPG APGPPGSPGP AGPTGKQGDR GEAGAQGPMG PSGPAGARGI AGPQGPRGDK GEAGEPGERG LKGHRGFTGL QGLPGPPGPS GDQGTSGPAG PSGPRGPPGP VGPSGKDGSN GIPGPIGPPG PRGRSGETGP AGPPGNPGPP GPPGPPGPGI DMSAFAGLGQ REKGPDPLQY MRA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

Gene References into Functions

These findings suggest a novel mechanism of action of SOX5/6; namely, the SOX9/5/6 combination enhances Col2a1 transcription through a novel enhancer in intron 6 together with the enhancer in intron 1. PMID:27881681
The ERK1/2 and Smad2/3 signaling pathways regulate type II collagen and aggrecan expression in rat chondrocytes. PMID:26165845
Local adipose tissue stem cells protected the bronchial stump after pneumonectomy and induced local changes in Col2a1 gene expression. PMID:24647564
Rat collagen II citrullination decreased the adhesion of human synovial fibroblasts and rat mesenchymal stem cells by decreasing the binding of integrins alpha10beta1 and alpha11beta1 (but not alpha1beta1 and alpha2beta1)to Arg-containing motifs. It decreased MSC survival. PMID:24823363
Screening of the Col2a1 gene, and enhancer domain, for the sequence encoded regulation of its expression. PMID:23019346
While urinary C-telopeptide of type II collagen was significantly increased during the experimental periods, serum type II procollagen-C-peptide was significantly decreased at the early phase. PMID:19000792
immunohistochemical findings are consistent with the concept that the major source of serum c-telopeptide type Ii is the damaged articular cartilage in collagen-induced arthritis. PMID:16947421
Substate stiffness regulates the gene expression of Col1alpha1, Col2alpha1, aggrecan, MMP-3, MMp-13, and ADAMTS-5 in rat annular (intervertebral disc) cells. PMID:21055467
important role of Col2a1 gene strong interaction sites on Col2a1 transcription regulation by SOX9 PMID:20404928
Second harmonic generation intensity as a function of the excitation polarization angle for type I and type II collagens, was measured. PMID:20875682
study found gene transcripts of type II and X collagen were most abundant at day 10 postnatally in the spheno-occipital synchondrosis PMID:20591638
results suggest that COLII is more immunogenic and arthritogenic in an acidic environment than in a neutral environmen PMID:15324928
The present study shows the reduced Col II expression in hypothyroid rat ovary, with the concomitant increase in Col II degradation. This information will be useful for further studies on reproductive disorders. PMID:17310101
Dysregulated genes expressed in rats with surgically-induced osteoarthritis included Mmp13, Adamts5, Ptges, Cxcr4, Ccl2, and Col2a1. PMID:17530714
Cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles. PMID:18304733
During pubertal growth spurt, two-week static compression reduced caudal vertebrae growth rates; this mechanical growth modulation occurred with decreased type II and X collagen proteins in the growth plate. PMID:18849019
Data reveal that COL2 is attacked at a susceptible peptide bond at the surface of developing articular cartilage canals, and is cleaved by MMP-13. PMID:19441084
mechanical stress from a functional lateral shift of the mandible have effects the expression of type II collagen PMID:19537875