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Recombinant Rat Ciliary neurotrophic factor receptor subunit alpha (Cntfr)

Recombinant Rat Ciliary neurotrophic factor receptor subunit alpha (Cntfr)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Cntfr

Purity

>85% (SDS-PAGE)

Target Names

Cntfr

Uniprot NO.

Q08406

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

23-342

Target Protein Sequence

QKHSPQEA PHVQYERLGT DVTLPCGTAS WDAAVTWRVN GTDLAPDLLN GSQLILRSLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LSAPTYIPNT FNVTVLHGSK MMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN TTAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS NGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL SS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Binds to CNTF. The alpha subunit provides the receptor specificity.

Gene References into Functions

the data suggest that endogenous CNTF receptor signaling in type B stem cells inhibits adult neurogenesis, and further suggest that the regulation may occur in a neuron subtype-specific manner. PMID:23325260
CNTF receptor-alpha is transiently expressed in the cerebral cortex surrounding the hematoma following induction of intracerebral hemorrhage, with a peak at 5 days. PMID:15755520

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Families

Type I cytokine receptor family, Type 3 subfamily

Tissue Specificity

Nervous system.

Database Links

UNIGENE: Rn.55036

KEGG: rno:313173

STRING: 10116.ENSRNOP00000066185

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