Recombinant Rat Chromogranin-A (Chga)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Chga

Uniprot NO.

P10354

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

19-466

Target Protein Sequence

LP VNSPMTKGDT KVMKCVLEVI SDSLSKPSPM PVSPECLETL QGDERVLSIL RHQNLLKELQ DLALQGAKER AQQQQQQQQQ QQQQQQQQQQ QHSSFEDELS EVFENQSPAA KHGDAASEAP SKDTVEKRED SDKGQQDAFE GTTEGPRPQA FPEPKQESSM MGNSQSPGED TANNTQSPTS LPSQEHGIPQ TTEGSERGPS AQQQARKAKQ EEKEEEEEEK EEEEEEKEEK AIAREKAGPK EVPTAASSSH FYSGYKKIQK DDDGQSESQA VNGKTGASEA VPSEGKGELE HSQQEEDGEE AMAGPPQGLF PGGKGQELER KQQEEEEEEE RLSREWEDKR WSRMDQLAKE LTAEKRLEGE DDPDRSMKLS FRARAYGFRD PGPQLRRGWR PSSREDSVEA RGDFEEKKEE EGSANRRAED QELESLSAIE AELEKVAHQL QALRRG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Strongly inhibits glucose induced insulin release from the pancreas.; Catestatin inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.; Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAMP/PKA pathway.

Subcellular Location

Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle. Secreted.

Protein Families

Chromogranin/secretogranin protein family

Tissue Specificity

Expressed in the brain and adrenal and pituitary glands.

Database Links

UNIGENE: Rn.41024

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