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Recombinant Rat Chitinase-3-like protein 1 (Chi3l1)

Recombinant Rat Chitinase-3-like protein 1 (Chi3l1)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Chi3l1

Purity

>85% (SDS-PAGE)

Target Names

Chi3l1

Uniprot NO.

Q9WTV1

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

20-381

Target Protein Sequence

Y KLVCYYTNWS QYREGNGSCF PDALDHSLCT HIIYSFANIS NNKLSTSEWN DVTLYGMLNT LKTRNPRLKT LLSVGGWSFG SERFSRIVSN AKSRKTFVQS VAPFLRTYGF DGLDLAWLYP GPKDKQHFTT LIKELKAEFT KEVQPGTEKL LLSAAVSAGK VTLDSGYDVA QIAQHLDFIN LMTYDFHGTW RHTTGHHSPL FRGQQDTGPD RFSNVDYGVG YMLRLGAPTN KLVMGIPTFG KSFTLASSEN QVGAPITGSG LPGRYTKEKG TLAYYEICDF LRGAEVHRIL GQQVPFATKG NQWVGYDDPE SVKNKVKYLK NKQLAGAMVW AVDLDDFRGS FCGHNVHFPL TNAIKEALAV A
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Gene References into Functions

Results showed that protein and mRNA levels of CHI3L1 decreased in normal cartilage but increased in osteoarthritic cartilage. PMID:26978347
NGF-treated tissue showed increased expression of CHI3L1 which was inhibited by the presence of Ro 08-2750 in intervertebral disk cells. PMID:25062286
Data show that hepatic CD14+ cells are an YKL-40(Chi3L1)mRNA and protein source in acute and chronic liver injury, with expression patterns similar to growth factors implicated in inflammation-fibrogenesis PMID:21987626

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Subcellular Location

Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Protein Families

Glycosyl hydrolase 18 family

Database Links

UNIGENE: Rn.68940

KEGG: rno:89824

STRING: 10116.ENSRNOP00000065787

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