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Recombinant Rat Cell surface glycoprotein MUC18 (Mcam), partial

Recombinant Rat Cell surface glycoprotein MUC18 (Mcam), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details

Abbreviation

Mcam

Purity

>85% (SDS-PAGE)

Target Names

Mcam

Uniprot NO.

Q9EPF2

Alternative Names

Mcam; Muc18; Cell surface glycoprotein MUC18; Gicerin; Melanoma cell adhesion molecule; Melanoma-associated antigen MUC18; CD antigen CD146

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene References into Functions

Alterations in CD146 are involved in the basic etiology of COPD/pulmonary emphysema. PMID:23649916
Gicerin might promote the interaction of tumor cells with a hepatic endothelium, thus leading to the hepatic metastasis of colon adenocarcinomas. PMID:21042736
expression of gicerin was increased in the rat carotid arteries after balloon injury. Gicerin might be involved in the arteriosclerotic neointima formation in the artery. PMID:14706627
Increase of gicerin expression by NGF promotes the gicerin-gicerin homophilic interaction resulting in the neurite extension. PMID:15880440

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Perikaryon. Note=Detected at the surface of the cell body of motor neurons.

Tissue Specificity

Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippoca

Database Links

UNIGENE: Rn.2694

KEGG: rno:78967

STRING: 10116.ENSRNOP00000010464

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