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Recombinant Rat Cell surface glycoprotein CD200 receptor 1 (Cd200r1), partial

Recombinant Rat Cell surface glycoprotein CD200 receptor 1 (Cd200r1), partial

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cd200r1

Uniprot NO.

Q9ES58

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli.

Gene References into Functions

CD200R in the rat is mainly expressed on myeloid cells but also on non-myeloid cell subsets, and rat cytomegalovirus e127 can deliver inhibitory signals to immune cells by engaging CD200R. PMID:30032349
In the context of an acute response, CD200 potently interferes with local immunopathogenic mechanisms, most likely through the activation of CD200R. PMID:25569356
Results suggest that dysfunction of CD200-CD200R signalling may be involved in the aetiopathogenesis of Parkinson disease. PMID:22053982
We show that the rat cytomegalovirus CD200 orthologue (e127) binds CD200R on rat peritoneal macrophages. PMID:21471232
The CD200-CD200R pathway seems of critical relevance for macrophage-mediated damage in autoimmune inflammation of the CNS. PMID:18164423