Recombinant Rat Caveolin-2 (Cav2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Cav2

Purity

>85% (SDS-PAGE)

Target Names

Cav2

Uniprot NO.

Q2IBC5

Alternative Names

Cav2Caveolin-2

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-162

Target Protein Sequence

MGLETEKADV QLFMADDAYS HHSVVDYTDP EKYVDSSQDR DPHQLNSHLK LGFEDLIAEP PTTHSFDKVW ICSHALFEIS KYVIYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVV IGPLCTSVGR IFSSVSMQLS HD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.

Gene References into Functions

The localisation and expression of caveolin 2 in luminal uterine epithelium at the time of implantation suggest a role in trafficking proteins and the maintenance of a polarised epithelium. PMID:24953158
show that Cav-2 is an epigenetic regulator of histone H3 modifications, and provide novel mechanisms of insulin-response epigenetic activation at the nuclear periphery PMID:25753664
Cav2 translocates to inner nuclear membrane in response to insulin via Rab6 mediated pathway. PMID:22607032
caveolin-2 protein expression and immunoreactivity were reduced in bladder smooth muscle at 6 and 12 months of age compared with young animals. PMID:22374691
Insulin-activated extracellular signal-regulated kinase (ERK) is translocated to the nuclear envelope by caveolin-2. PMID:20455999
The phosphorylation of tyrosine 19-caveolin-2 is required for actin cytoskeleton-dependent ERK nuclear import. PMID:19778377
lipid raft-dependent tyrosine phosphorylation of caveolin-2 may be a critical regulator of P. aeruginosa invasion PMID:15545264
Caveolin-2 is expressed constitutively in vascular endothelial cells and ependymal cells of normal rat spinal cord; the expression level begins to increase when experimental autoimmune encephalitis is initiated. PMID:15925413

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Subcellular Location

Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.

Protein Families

Caveolin family

Tissue Specificity

In the retina, mainly expressed in vessels, but also diffuse expression in the inner and outer plexiform layers and in the inner nuclear layer.

Database Links

UNIGENE: Rn.81070

KEGG: rno:363425

STRING: 10116.ENSRNOP00000008722

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