Recombinant Rat Caspase-12 (Casp12), partial

1. these results suggest that emodin inhibits SIRS in rats with SAP by inducing circulating neutrophil apoptosis via the Ca(2+)-calpain 1-caspase 12-caspase 3 signaling pathway PMID:28078280
2. caspase-12 plays an important role in stretch-induced apoptosis that is associated by endoplasmic reticulum stress by activating caspase-3. PMID:26801321
3. Tauroursodeoxycholic acid inhibits the expression of caspase-12 in rat neurons after spinal cord injury, reducing apoptosis and exerting neuroprotective effects. PMID:26884858
4. Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. PMID:26261584
5. This study demonstred that caspase-12 mRNA in the hippocampus was elevated in subarachnoid hemorrhage animals. PMID:25219918
6. SMI could alleviate myocardial ER stress and caspase-12 dependent apoptosis, which subsequently helped to improve the heart function of rats with DOX-CM. PMID:25839043
7. Results showed that, following thapsigargin treatment, more Purkinje neuron dendrites in the ethanol-fed group expressed activated caspase 12 PMID:24976582
8. Activation of endoplasmic reticulum stress increases apoptosis and expression of CASP12 in the renal cortex of diabetic rats. PMID:21845883
9. The protective mechanisms of fused FNK protein therapy might involve the inhibition of apoptotic pathways through caspase-12, but not through Bcl-2. PMID:22099262
10. Mitochondrial caspase-9 is not a downstream substrate of endoplasmic reticulum-specific caspase-12 . PMID:21784110
11. Processing of procaspase-12 was mediated by NMDA receptor and calpain activation PMID:21525936
12. This result suggests that the fragmentation of caspase-12 and the subsequent nuclear translocation of these fragments are involved in the brain infarction process in rats. PMID:21476018
13. Electrical stimulation increased valosin-containing protein (VCP) expression and decreased cleaved caspase-12 expression in denervated muscles. PMID:20871144
14. both the PERK/eIF2 alpha/ATF4 ISR and activation of caspase-12 may be involved in apoptosis of spinal cord astrocytes induced by OGSD/restoration. PMID:20444431
15. Spinal cord injury induced greater spinal cord caspase 12 expression in diabetic vs non diabetic rats. PMID:19215662
16. Na/Ca exchanger overexpression, by depleting ER Ca(2+) stores, triggers the activation of caspase-12 and increases apoptotic cell death PMID:12031969
17. Immunohistochemical analysis reveals diffuse positive immunostaining of caspase-12 throughout the striatum and cerebral cortex in animals that undergo ischemia, with more intense caspase-12 staining in post-ischemic striatum than in post-ischemic cortex. PMID:12598725
18. caspase-12 induction was noted in neurons in both the cortex and hippocampus as well as in astrocytes at the contusion site after traumatic brain injury PMID:14675152
19. a striking approximately 350% increase in the expression of procaspase-12 (caspase located at the sarcoplasmic reticulum) PMID:14732288
20. inactivation of caspase-12 via the NGF-mediated PI3-K signaling pathway leads to inactivation of the caspase cascade including caspase-3 and -9 PMID:15113843
21. Doxorubicin treatment in vivo activates casp12-mediated cardiac apoptosis in both male and female rats. PMID:15556633
22. Increased ER stress-induced apoptosis and activation of caspase-12 were observed in IRPTCs with albumin overload and kidneys of experimental proteinuric rats. PMID:16955111
23. These results suggest that TM elicits subregion-specific neuronal toxicity in OHC and that the vulnerability to TM-induced toxicity is at least partly dependent on the expression level of endogenous procaspase-12 in each area of the hippocampus. PMID:18280615
24. proteolytic activity of caspase-12 is confined to its own proenzyme PMID:18332441

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UNIGENE: Rn.81078

KEGG: rno:156117

STRING: 10116.ENSRNOP00000010244