Home
Product
Protein
Recombinant Proteins
Recombinant Rat Cardiac phospholamban (Pln), partial

Recombinant Rat Cardiac phospholamban (Pln), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Pln

Uniprot NO.

P61016

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Gene References into Functions

Long-term in vivo administration of GTE improves cell mechanical properties and intracellular calcium dynamics in normal cardiomyocytes, by increasing energy availability and removing the inhibitory effect of PLB on SERCA2. PMID:29913456
results confirm that AKAP7gamma/delta binding to PLB is important for phosphorylation of PLB. PMID:26027516
In reperfused control hearts, inhibition of phospholamban phosphorylation or SERCA (thapsigargin) simulated the cardioprotective effects of ischaemic post-conditioning PMID:25020913
Diminished phosphorylation of phospholamban by anthrax lethal toxin resulted in acute diastolic heart failure. PMID:23907041
Time course and mechanisms of phosphorylation of phospholamban residues in ischemia-reperfused rat hearts. Dissociation of phospholamban phosphorylation pathways PMID:11812163
the interaction between phospholamban phosphorylation and Ca2+ transport across the SR was disrupted during the early phase of sepsis. PMID:12022759
Maximal inhibition of Ca-ATPase by phospholamban expressed in either slow-twitch skeletal or cardiac muscle is observed at a stoichiometry of 1 mol of Plm per mol of Ca-ATPase. PMID:12403631
although both phospholamban phosphorylation sites are involved in the mechanical recovery after myocardial ischemia, Thr17 appears to play a major role. PMID:12763747
Paraplegia significantly increased the relative protein abundances of SERCA (45%) and the Na/Ca exchanger (40%) and decreased phospholamban levels (-28%)in the heart. PMID:12881214
higher levels of MHC-beta and dephosphorylated PLB may contribute to more contractile dysfunction in male than in female diabetic rat hearts, and that phosphorylation of PLB at threonine 17 is more responsive to insulin in female diabetic rat hearts. PMID:12933346
phospholamban expression is regulated in cardiac myocytes by adenylyl cyclase VI via activating transcription factor 3 PMID:15231818
the phosphorylation of Thr17 of phospholamban upon reflow, may favor the full recovery of relaxation after myocardial ischemia-reperfusion injury PMID:15524173
Beneficial effects of intermittent high altitude hypoxia on threonine phosphorylation and calcium pump. PMID:15637115
The expression of SLN and PLB mRNA and protein relative to SERCA1 or SERCA2 was assessed in ventricle, atrium, and skeltal msucle of mouse, rat, rabbit and pig. PMID:15801907
prevent sustained CaMKII autophosphorylation PMID:17239900
Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban. PMID:19074672

Hide All

Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein.

Protein Families

Phospholamban family

Tissue Specificity

Heart.

Database Links

UNIGENE: Rn.9740

KEGG: rno:64672

STRING: 10116.ENSRNOP00000000469

Promotions