Recombinant Rat Calretinin (Calb2)

Code
MSDS	MSDS
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Calb2

Uniprot NO.

P47728

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-271

Target Protein Sequence

MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL TTYRKSVMSL AEAGKLYRKD LEIVLCSEPP M

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Gene References into Functions

Quantitative analysis of the transient changes in calretinin expression by hybridochemistry within neuronal cell populations in the hippocampus of a beta amyloid-treated rat model of Alzheimer's disease and their correlation with endocannabinoid increase PMID:25813826
A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel PMID:25730969
distribution of the cell-specific markers, calretinin and calbindin, in reelin-immunoreactive cells during postnatal rat and mouse neocortical development PMID:24134921
The stress of maternal deprivation has a significant effect on calretinin and calbindin expression in both male and female ratss, but affects glucocorticoid receptor levels only in males. PMID:21835217
An essential property of calretinin action potentials is a delayed equilibration with divalent calcium ions. PMID:21394464
study concludes that, in inner and outer enamel epithelial cells, Ca(2+)is regulated by calbindin, parvalbumin and calretinin during tooth development; in epithelial rests of Malassez of adult periodontal ligament, Ca(2+) is regulated only by calretinin PMID:21080000
CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats. PMID:11834306
Calretinin-positive cells predominantly comprise caudally or locally projecting, possibly glutamatergic basal forebrain neurons PMID:12577320
CR-IR cells of the neostriatum are a distinct subclass of interneurons that are born at an intermediate time during striatal development and share common neurogenesis characteristics with other interneurons. PMID:14730585
These data clearly show that expression of CR gene in neurons and cancer cells is regulated by different mechanisms. On the other hand, in both cell types, the activity of CR gene promoter can be stimulated by zinc ions. PMID:15093134
In rats, calretinin-containing calyces were irregularly interspersed with calretinin-negative calyces and The percentage of calretinin-positive calyces increased during development, to about 75% and 20% at P30 PMID:15355314
Data show that virtually all newly produced striatal neurons are calretinin (CR)-immunoreactive (+), but not DARPP-32(+), calbindin-D-28K(+), parvalbumin(+), somatostatin(+), or choline acetyltransferase(+). PMID:18720478