Home
Product
Protein
Recombinant Proteins
Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta (Camk2b)

Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta (Camk2b)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Camk2b

Uniprot NO.

P08413

Alternative Names

Camk2b; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; EC 2.7.11.17

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-542

Target Protein Sequence

MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK NSSAITSPKG SLPPAALEPQ TTVIHNPVDG IKESSDSTNT TIEDEDAKAR KQEIIKTTEQ LIEAVNNGDF EAYAKICDPG LTSFEPEALG NLVEGMDFHR FYFENLLAKN SKPIHTTILN PHVHVIGEDA ACIAYIRLTQ YIDGQGRPRT SQSEETRVWH RPDGKWQNVH FHCSGAPVAP LQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Gene References into Functions

VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation. PMID:25644714
Results suggest that a sodium-dependent glutamate transporter-CaMKIIbeta-actin cytoskeleton axis plays an important role in the regulation of oligodendrocyte maturation and central nervous system myelination PMID:24866099
BDNF-induced CaMKIIbeta phosphorylation and premature synapse formation were suppressed in GIT1 (S419A) transfected cortical neurons PMID:23352984
These results identify betaCaMKII as a powerful regulator of lateral habenula neuron function and a key molecular determinant of depression. PMID:23990563
Study shows targeting of Arc to inactive synapses via a high-affinity interaction with CaMKIIbeta that is not bound to calmodulin. PMID:22579289
Activation of intracellular CaMKII signaling in the pedunculopontine tegmental nucleus promotes wakefulness and suppresses sleep. PMID:22114270
The beta isoenzyme of Ca(2+)/calmodulin-dependent kinase type II as possible mediator of somatostatin functions in pituitary tumour cells PMID:21952434
play distinct role during the development of the retina. PMID:12234658
Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. PMID:12873385
Activities of both enzymes increased upon their association, and iPLA(2)beta reaction products reduced CaMKIIbeta activity PMID:15576376
CaMKIIbeta binding to NR2B C-tail was examined. Translocation was observed for CAMKIIbeta. Ionomycin dispersed CaMKIIbeta into a punctate pattern. PMID:16436603
F-actin-targeted CaMKIIbeta, but not alpha, was able to phosphorylate actin in vitro even by nonstimulated basal activity. PMID:16928958
Study suggest that Camk2a is not involved in regulating the acute ethanol sensitivity of NMDA receptors. PMID:18562151
endogenous CaMKIIbeta, but not CaMKIIalpha, localized to prominent F-actin-rich structures at the soma in embryonic cortical neurons. PMID:18840684
CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling. PMID:19047462

Hide All

Subcellular Location

Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the cortical actin cytoskeleton by binding to F-actin in hippocampal cells.

Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily

Database Links

UNIGENE: Rn.9743

KEGG: rno:24245

Promotions