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Recombinant Rat Calcium-activated potassium channel subunit beta-1 (Kcnmb1), partial

Recombinant Rat Calcium-activated potassium channel subunit beta-1 (Kcnmb1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Kcnmb1

Uniprot NO.

P97678

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

Gene References into Functions

Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2. PMID:28487419
n-3 PUFAs protect the coronary BK channel function and coronary vasoreactivity in diabetic rats as a result of not only increasing BK-beta1 protein expressions, but also decreasing coronary artery tension and coronary smooth muscle cytosolic Ca2+ concentrations. PMID:29040972
Data show that leukotriene B4, but not other leukotrienes of the LT4 family, activates recombinant (cbv1-beta1) Lrge-conductance calcium-activated potassium (BK) channels. PMID:25371198
aging decreases capability of MaxiK channel in regulating vascular tone in the MA, which may be partially mediated by unparallel downregulation of alpha- and beta1-subunit expression PMID:24051206
The expression of BK(Ca) beta1- but not alpha-subunit was significantly enhanced after exercise training PMID:22660813
BKbeta1 transcripts and protein are detected in several astrocytic populations and cultured cells, to a lesser degree than BKbeta4 channels. PMID:21438011
KCNMB1 was the dominant beta subunit in the ductus arteriosus, and the amount of beta1 mRNAs was greatest in the mature DA. PMID:20936291
Immunocytochemical staining of rat hypothalamic neurons indicates strong BKbeta1 expression in the supraoptic nucleus and the magno- and parvocellular parts of the paraventricular nucleus. PMID:20443052
ageing was associated with a reduction in BK(Ca) channels, and exercise training (ET) partly reversed this reduction. low-intensity ET may be beneficial in restoring age-related decline in coronary vasodilatory properties mediated by BK(Ca) channels. PMID:20139169
Downregulation of BKCa channel beta1-subunit in the type-2 diabetic cerebral artery smooth muscle cells contributes to cerebral vascular complication in type-2 diabetes via reducing activity of BKCa channels, increasing vascular tone and blood pressure. PMID:20334613
Kvbeta 1.1 contributes to the developmental control of the A-typepotassium channel current in hippocampal neurons. PMID:12890510
lower expression of the beta1 subunit during genetic borderline and severe hypertension reduced BK channel activity by decreasing the sensitivity of these channels to physiological changes in Ca2+ PMID:14551242
activation of specific PKC isozymes increases BK(Ca)-channel activity in Sprague-Dawley rat PASMC via cyclic GMP-dependent protein kinase, which suggests a unique signaling mechanism for vasodilatation. PMID:14966080
Increased BK beta1 expression in mesenteric arteries may represent a compensatory reaction to limit the development of hypertension. PMID:16814121
DiBAC(4)(3) activated whole-cell BKalphabeta1 and BKalphabeta4 currents in the same concentration range but partially blocked BKalphabeta2 currents. Structure activity relationships are discussed. PMID:17209121
The large conductance (BK) beta 1 channel subunit confers Ca2+-sensitivity to BK channel complexes, and both transcript and protein levels for BK beta 1 were appreciably lower in diabetic retinal arterioles. PMID:17293477
There is a selective distribution of auxiliary beta1 subunits to the somatic and dendritic compartments and beta4 subunits to the terminal compartment of neurons in the hypothalamic-neurohypophysial system. PMID:19321803