Recombinant Rat Calcipressin-1 (Rcan1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

Rcan1

Purity

>85% (SDS-PAGE)

Target Names

Rcan1

Uniprot NO.

Q6IN33

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-199

Target Protein Sequence

MHFRDFNYNF SSLIACVANG DVFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEEEEE EEEEMERMKR PKPKIIQTRR PEYTPIHLS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

Gene References into Functions

RCAN1 plays a critical role in spinal cord injury. PMID:27339639
We propose that increased RCAN1-4 expression and the signal transduction pathways it regulates represent important components of the physiological adaptation to exercise-induced oxidative stress. PMID:26122706
Rcan1 downregulation impaired neural progenitor proliferation and led to defects in radial migration and periventricular heterotopia. PMID:25589755
RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells PMID:22389495
DSCR1 overexpression attenuates NFAT transcriptional activity in vascular smooth muscle cells. PMID:19926569
In the heart MCIP1 gene is activated by calcineurin and has been proposed to fulfill a negative feedback loop that restrains potentially pathological calcineurin signaling PMID:14976250
role in skeletal muscle innervation in increasing levels PMID:15219871
induction of MCIP1 antagonizes calcineurin-related hypertrophy in cardiac myocytes PMID:15899894
calcineurin-dependent induction of DSCR1.4 product may represent an important auto-regulatory mechanism for the homeostatic control of NFAT signaling in neural cells. PMID:15975916
NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1 PMID:18056702
RCAN1 is a novel ATF6-inducible gene that may also be a novel integrator of growth and ER stress signaling in many other tissues that depend on calcineurin/NFAT signaling for optimal growth and development PMID:18319259