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Recombinant Rat CDK5 regulatory subunit-associated protein 2 (Cdk5rap2)

Recombinant Rat CDK5 regulatory subunit-associated protein 2 (Cdk5rap2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Cdk5rap2

Purity

>85% (SDS-PAGE)

Target Names

Cdk5rap2

Uniprot NO.

Q9JLH5

Alternative Names

Cdk5rap2CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-218

Target Protein Sequence

MAPKSASETP VLSGTDVDSL SCDSTSSATS PSCMPCLVAG RHLWASKSGH HMLCLIEDYD ALYKQISWGQ TLLAKMDIQT QEALSPTSQK LGPKASFSVP LSKFLSSMNT AKLILEKASR LLKLFWRVSV PTNGQCSLHC DQIGEMKAEI TKLHKKLFEQ EKKLQNTAKL LQQSKHQEKI IFDQLVITHQ VLRKARGNLE LRPRAAHPGT SSPSRPGS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes. Plays a role in neurogenesis. Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear.

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Cytoplasm.

Database Links

UNIGENE: Rn.13247

STRING: 10116.ENSRNOP00000007710

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