Recombinant Rat CD40 ligand (Cd40lg), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Cd40lg

Purity

>85% (SDS-PAGE)

Target Names

Cd40lg

Uniprot NO.

Q9Z2V2

Alternative Names

Cd40lg; Cd40l; Tnfsf5CD40 ligand; CD40-L; Tumor necrosis factor ligand superfamily member 5; CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form; sCD40L)]

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.; Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.

Gene References into Functions

Transient middle cerebral artery occlusion (MCAO) rats yielded an acceleration of thrombus formation that was accompanied by increased CD40 levels in serum. The brain infarction was significantly decreased in CD40 antagonist treatment group compared to MCAO model group. The mTOR/S6K signaling was activated in MACO model than that of CD40 antagonist treatment group. PMID:29843579
Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis. PMID:29155846
Suggest that CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury. PMID:25993320
These data suggest that placental ischemia-induced T-cell communication via the CD40L is one important mechanism leading to much of the pathophysiology of preeclampsia. PMID:26310940
PSB33 functions in the maintenance of photosystem II-light-harvesting complex II.[PSB33] PMID:25511433
Data suggest that astrocytes activated by CD40-CD40L in co-culture induce inflammatory cytokine production, and secreted cytokines re-activate astrocytes via Jak/STAT1701 pathways, and release more cytokines that contribute to the development of EAE. PMID:21410936
Monoclonal antibodies are immunosuppressive in pig to rat islet xenograft. PMID:15665763
B cells play a cooperative role via CD40L-CD40 interaction in T cell-mediated experimental autoimmune neuritis of Lewis rats PMID:17188497
HO-1 mitigated CD40L transcription in the xenograft and recipient spleen. PMID:17976119
Generated and characterized a novel anti-rat CD40L antibody with inhibitory activities. PMID:18384807
Adenovirus-mediated Cd40lg gene therapy induced both humoral and cellular immunity against rat model of hepatocellular carcinoma. PMID:19016771
Primary tumor cells obtained from MNU-induced mammary carcinomas show immune heterogeneity which can be modulated by low-efficiency transfection of CD40L gene. PMID:19164932