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Recombinant Rat Breast cancer anti-estrogen resistance protein 1 (Bcar1), partial

Recombinant Rat Breast cancer anti-estrogen resistance protein 1 (Bcar1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Bcar1

Purity

>85% (SDS-PAGE)

Target Names

Bcar1

Uniprot NO.

Q63767

Alternative Names

Bcar1; Cas; CrkasBreast cancer anti-estrogen resistance protein 1; CRK-associated substrate; p130cas

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-968

Target Protein Sequence

MKYLVSVGAG PARRAGGLED VSWGPRVSRR PQSYRAARHV NESLPRSAFR VPAAHGASVT PSAALGSGLP ETQPEAVCRG TEKPRFAEGC KPAASRDKNV LAKALYDNVA ESPDELSFRK GDIMTVLERD TQGLDGWWLC SLHGRQGIVP GNRLKILVGM YDKKPAAPGP GPPATPPQPQ PSLPQGVHTP VPPASQYSPM LPTAYQPQPD NVYLVPTPSK TQQGLYQAPG PNPQFQSPPA KQTSTFSKQT PHHSFPSPAT DLYQVPPGPG SPAQDIYQVP PSAGTGHDIY QVPPSLDTRS WEGTKPPAKV VVPTRVGQGY VYEASQAEQD EYDTPRHLLA PGSQDIYDVP PVRGLLPNQY GQEVYDTPPM AVKGPNGRDP LLDVYDVPPS VEKGLPPSNH HSVYDVPPSV SKDVPDGPLL REETYDVPPA FAKPKPFDPT RHPLILAAPP PDSPPAEDVY DVPPPAPDLY DVPPGLRRPG PGTLYDVPRE RVLPPEVADG SVIDDGVYAV PPPAEREAPT DGKRLSASST GSTRSSQSAS SLEVVVPGRE PLELEVAVET LARLQQGVST TVAHLLDLVG SASGPGGWRS TSEPQEPPVQ DLKAAVAAVH GAVHELLEFA RSAVSSATHT SDRTLHAKLS RQLQKMEDVY QTLVVHGQVL DSGRGGPGFT LDDLDRLVAC SRAVPEDAKQ LASFLHGNAS LLFRRTKAPG PGPEGSSSLH LNPTDKASSI QSRPLPSPPK FTSQDSPDGQ YENSEGGWME DYDYVHLQGK EEFEKTQKEL LEKGNIVRQG KGQLELQQLK QFERLEQEVS RPIDHDLANW TPAQPLVPGR TGGLGPSDRQ LLLFYLEQCE ANLTTLTDAV DAFFTAVATN QPPKIFVAHS KFVILSAHKL VFIGDTLSRQ AKAADVRSKV THYSNLLCDL LRGIVATTKA AALQYPSPSA AQDMVDRVKE LGHSTQQFRR VLGQLAAA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling.

Gene References into Functions

Cas plays pivotal roles in liver development through the reorganization of the actin cytoskeleton and formation of fenestrae in sinusoidal endothelial cells. PMID:20623582
Analysis of protein domains of Cas protein in rat. PMID:12011056
degradation of p130cas during apoptosis is modulated in a phosphorylation-dependent manner PMID:12480533
in cells transformed by the v-crk oncogene, the adapter protein Cas forms a stable complex with the p85 regulatory subunit of phosphatidylinositol 3'-kinase (PI3K) coincident with the appearance of Cas-associated PI3K activity PMID:12692262
upregulation of PTP-PEST is both necessary and sufficient to explain NO-induced p130cas dephosphorylation in vascular smooth muscle PMID:12714323
tyrosine phosphorylation of Crk-associated substrate in pancreatic beta-cells is stimulated by glucose PMID:12746446
glutamic acid mutation of tyrosine 635 makes SHEP1 unable to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal growth factor (EGF), implying that these activities of SHEP1 depend upon a physical interaction with Cas PMID:15272013
functional domain analysis of the docking protein p130Cas PMID:15485652
the solution structure shows that the p130cas serine-rich domain is a four-helix bundle PMID:15795225
Data suggest that IGF-I induces smooth muscle cell motility by increasing phosphotyrosine levels of p130(cas) and activating Rac1, and that nitric oxide decreases motility by activating PTP-PEST. PMID:16354758
These data are the first to implicate Crk-associated substrate in the signal transduction of 5-HT. PMID:16861698
Abl may play a pivotal role in mediating CAS phosphorylation, the assembly of the multiprotein complex, actin assembly, and constriction in resistance arteries PMID:17615370
Caspase-mediated cleavage of p130Cas generates a 31 kDa fragment, inhibits p21Cip1 transcription and acts as an amplifier of apoptotic signalling PMID:17617061