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Recombinant Rat Bone morphogenetic protein receptor type-1A (Bmpr1a), partial

Recombinant Rat Bone morphogenetic protein receptor type-1A (Bmpr1a), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Bmpr1a

Purity

>85% (SDS-PAGE)

Target Names

Bmpr1a

Uniprot NO.

Q78EA7

Alternative Names

Bmpr1a; Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; EC 2.7.11.30; Activin receptor-like kinase 3; ALK-3; Bone morphogenetic protein 4 receptor; CD antigen CD292

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.

Gene References into Functions

Expression of BMPR IA increases significantly in the astrocytes and activated microglia cells in rats after contusive spinal cord injury. PMID:21764678
JNK1 activation decreases binding of inhibitory Smad6 to the type I BMP receptor. PMID:21542012

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell surface.

Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily

Database Links

UNIGENE: Rn.88925

KEGG: rno:81507

STRING: 10116.ENSRNOP00000015047

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