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Recombinant Rat Bile salt export pump (Abcb11), partial

Recombinant Rat Bile salt export pump (Abcb11), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Abcb11

Uniprot NO.

O70127

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.

Gene References into Functions

bile acid homeostasis in rats was regulated through bile acid synthesis and transport in response to Bsep deficiency and roglitazone inhibition PMID:28645914
Ginsenoside promotion of hepatic cholesterol metabolism does not involve effects on BSEP. PMID:23108811
FXR regulates BSEP in an isoform-dependent and species-specific manner PMID:24002920
show that AP2 interacts with BSEP at the canalicular membrane through a tyrosine motif at the carboxyl terminus of BSEP PMID:22262466
Pericanalicular calcium signaling mediated by InsP3R2 plays an important role in maintaining bile salt secretion through posttranslational regulation of bile salt export pump. PMID:21748767
The inhibition of BSEP/Bsep resulted in significantly higher intracellular TC(conc) in humans than in rats. PMID:20147439
The Bsep gene has a suppressive element between nucleotides -800 and -512. 2 consensus sites for the farnesoid X receptor are at nucleotides -473 and -64. The latter is functionally active in bile-acid-mediated feedback of Bsep transcription. PMID:12135489
Ontogenic changes in bile formation are mediated in part by the regulation of expression of canalicular membrane transporter Bsep. PMID:12538788
results suggest changes in Bsep localization are involved in estradiol-17beta-D-glucuronide-induced impairment of bile flow and bile salt transport and DBcAMP prevents this effect by stimulating insertion of canalicular transporter-containing vesicles PMID:12702498
Silibinin prevents bile salt secretory failure by avoiding redistribution of Bsep by a mechanisms involving cyclic AMP and calcium. PMID:15763547
At least two N-linked glycans are required for ABCB11 protein stability, intracellular trafficking, and function in the apical membrane. PMID:17082223
In hypoxic liver tissue a marked reduction in the mRNA levels of bile salt export protein was detected before bile duct proliferation occurred. PMID:17615179
Clinical phenotypes of different types of intrahepatic cholestasis may directly correlate with the amount of mature protein that is expressed at the cell surface. PMID:17855769
In conclusion, zonal downregulation of Bsep in obstructive cholestasis is associated with portal inflammation and is mediated by TNF-alpha and IL-1beta. PMID:17916651
Taurocholate transport function was impaired in proportion to rapid degradation of Bsep protein mutants. These results may explain the phenotypic difference between BRIC2 and PFIC2. PMID:17947449
Hepatic expression of BSEP mRNA decreased after transplantation. PMID:18551070
Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11). PMID:18829893

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Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endosome. Cell membrane; Multi-pass membrane protein.

Protein Families

ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily

Tissue Specificity

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Database Links

UNIGENE: Rn.14539

KEGG: rno:83569

STRING: 10116.ENSRNOP00000064279

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