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Recombinant Rat Beclin 1-associated autophagy-related key regulator (Atg14)

Recombinant Rat Beclin 1-associated autophagy-related key regulator (Atg14)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Atg14

Uniprot NO.

D4A4K3

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-492

Target Protein Sequence

MASPSGKGSW TPEAPGFGPR ALAPDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ SGDFVYFDGR DRERFIDKKE RLSQLKNKQE EFQKEVLKAM EGKRLTDQLR WKIMSCKMRI EQLKQTICKG NEEMKKNSEG LLKNKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT SDLREHYDRL ACLRRLHILE LTSVIFPMDE VKTSGRDPAD VSSETDSAMT SSMVSKLAEA RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY NWVEEKKTTQ GPDMEHNNPA YTISAALGYA TQLVNIVSHI LDINLPKKLC NSEFCGENLS KQRLTRAVRK LNANILYLCS SQHVNLDQLQ PLHTLRNLMH LVSPHSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDVSG DERVSDEETD LGTDWENLPS PRFCDIPSQP VEVSQSQSTQ ASPPIASSSA GGMISSAAAS VTSWFKAYTG HR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism.

Subcellular Location

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein.

Protein Families

ATG14 family

Database Links

UNIGENE: Rn.47301

KEGG: rno:305831

STRING: 10116.ENSRNOP00000016274

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