Recombinant Rat Basigin (Bsg), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Bsg

Uniprot NO.

P26453

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors.; Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1 and SLC16A3 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells. Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids.

Gene References into Functions

EMMPRIN overexpressing subventricular zone neural progenitor cells invade ischemic cortical tissue more efficiently than controls. PMID:28716558
Upregulation of extracellular matrix metalloproteinase inducer (OX47) in rat dorsal root ganglion contributes to the development of mechanical allodynia after nerve injury. PMID:26697232
EMMPRIN regulates pressure ulcer healing by controlling the collagen content and angiogenesis rather than MMPs activity. PMID:26261551
EMMPRIN expression was increased following fluid percussion injury. EMMPRIN increased expression was temporally correlated with an increase in MMP-9 levels. CD147 and MMP-9 may play a role in vascular injuries after TBI. PMID:24968091
EMMPRIN/CD147-regulated metalloproteinases MMP-2 and MMP-14, associated with low MMP-3, appear as the main characteristics of extracellular matrix remodeling in early overused tendons. PMID:23404084
basigin may be involved in acute myocardial ischemia following continual ischemia for >30 min. PMID:23525302
EMMPRIN mediates induction of uterine and vascular matrix metalloproteinases during pregnancy. PMID:23856290
EMPRIN and cyclophilin-A play roles in the maturation of dental hard tissue and the formation of a molar eruption pathway. PMID:22139963
EMMPRIN and VEGF may play a role in radiation injuries of the central nervous system after gamma knife surgery PMID:22379341
High Extracellular matrix metalloproteinase inducer is associated with pediatric medulloblastoma. PMID:21448785
Basigin was involved in myocardium pathophysiology 30 minutes after myocardial ischemia. PMID:20369476
Molecular mass in cauda spermatozoa was approximately 28,000-26,000 Dalton. Capacitation induces minor posttranslational modifications in structure. Facilitates sperm-oocyte interactions. PMID:14645104
identified a single leucine (252) as the basolateral targeting motif in the cytoplasmic tail of CD147 PMID:15215314
Basigin espression profiles in induced-ovulation/corpus luteum regression models are similar to those in naturally cycling mature rats and significantly augmented to gonadotropin. PMID:15758150
These results raise the possibility that the increased expression of EMMPRIN, the increase in MMPs and the damage of the basal lamina following cerebral ischemia are connected and part of a network of related changes. PMID:16029217
bleomycin-induced lung injury is associated with an increase in CD147 expression and MMP activity, particularly in alveolar epithelial cells. our data exclude any functional interaction between CD147 & alveolar epithelial caveolin-1. PMID:16733664
These findings suggest that in the myocardium the regulated expression of EMMPRIN is a determinant of MMP activity and may thus play a role in myocardial remodeling. PMID:17869266
at low to moderate doses of rt-PA the microvascular basal lamina collagen IV was protected, probably due to inhibition of MMP-2 and MMP-9 by the upregulation of TIMP1, TIMP2, and EMMPRIN PMID:18000599
These findings suggest potential roles for basement membrane in the transcriptional regulation of tracheal epithelial EMMPRIN. PMID:18243135
Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMP2/9) as regulators of tumor-host interaction in a spontaneous metastasis model in rats. PMID:18769934

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein.

Tissue Specificity

[Isoform 2]: Expressed in the skeletal muscle, liver, small intestine, kidney, testis, brain, heart and spleen. Also present in various immature cells and endothelia.

Database Links

UNIGENE: Rn.2269

KEGG: rno:25246

STRING: 10116.ENSRNOP00000011275

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