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Recombinant Rat BH3-interacting domain death agonist (Bid)

Recombinant Rat BH3-interacting domain death agonist (Bid)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Bid

Purity

>85% (SDS-PAGE)

Target Names

Bid

Uniprot NO.

Q9JLT6

Alternative Names

BidBH3-interacting domain death agonist; p22 BID; BID) [Cleaved into: BH3-interacting domain death agonist p15; p15 BID); BH3-interacting domain death agonist p13; p13 BID); BH3-interacting domain death agonist p11; p11 BID)]

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-196

Target Protein Sequence

MDSEVSNGSG LGAEHITNLL VFGFLRNNDR DFHQELEVLG QELPVQVYLE GDREDELQTD GSRASRSFYH GRIEPDSESQ DEVIHNIARH LAQAGDELDH SIQPTLVRQL AAQFMNGSLS EEDKRNCLAK ALDEVKTSFP RDMENDKAML IMTMLLAKKV ASHAPSLLRD VFRTTVNFIN QNLFSYVRDL VRNEMD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Induces caspases and apoptosis. Counters the protective effect of BCL2.; Induces caspase activation and apoptosis. Allows the release of cytochrome c.

Gene References into Functions

By blocking he tBid-mitochondrial apoptotic signaling pathway, neuroprotection against cerebral ischemia is activated. PMID:24616078
data support the hypothesis that cleavage of Bid contributes to the apoptotic degeneration of different CNS cells in the injured cortex. PMID:12172380
Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein PMID:12193163
Bid activation in kidney cells follows ATP depletion in vitro and renal ischemia in vivo PMID:14678945
In contrast to Bax, another pro-apoptotic protein (Bid) proteolytically cleaved with caspase-8 affected the voltage gating of voltage-dependent anion channels by inducing channel closure. PMID:14729675
proapoptotic BAX and tBID have roles in lipidic pore formation PMID:15138279
tBid has a role in Bax regulation of the pore size of rat brain mitochondrial voltage-dependent anion channels PMID:15351738
tBid has a role in causing a conformational alteration in membrane-bound Bcl-2 that inhibits Bax pore formation PMID:17005564
Translocation of full Length-Bid is sufficient for the activation of mitochondrial cell death pathways in response to glutamate receptor overactivation. PMID:17326836
Suggest that estrogen protects the heart against ischemia reperfusion injury through the decrease of calpain activity, Bid cleavage and caspase-8 activity. PMID:18038901
tBid has a monofunctional action at low concentrations and basal cytochrome c diffusibility in the intermembrane spaces is adequate for rapid and complete cytochrome c release irrespective of outer membrane permeabilisation. PMID:18252800
act in synergy with Bax in T11TS-mediated glioma apoptosis PMID:18931364

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Subcellular Location

Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane.; [BH3-interacting domain death agonist p15]: Mitochondrion membrane.; [BH3-interacting domain death agonist p13]: Mitochondrion membrane.

Database Links

UNIGENE: Rn.31142

KEGG: rno:64625

STRING: 10116.ENSRNOP00000016776

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