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Recombinant Rat BAG family molecular chaperone regulator 1 (Bag1)

Recombinant Rat BAG family molecular chaperone regulator 1 (Bag1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Bag1

Uniprot NO.

B0K019

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-358

Target Protein Sequence

MADRGGARRP RGDQEPLGPR LRAPRSARET RQSESRAERG LPPSQRSSVR SAASGHDRST RGAASGACKP RVKKKVRPRS SQSEKVAHSK ELTRSKKLTR SKKVTGTQEA TQVEEVTTIE EATQTEEITV AEEVTQTENM AQTEEMVQTE EMEPPTLSVV VTHSNERYDL LVTPQQGNSE PIVQDLAQLV EEATGVPLPF QKLIFKGKSL KEMETPLSAL GMQNGCRVML IGEKSNPEEE AELKKLKDLE VSVEKTANHL EELNKELSDI QQGFLAKELQ AEALCRLDRK IKATIEQFMK ILEEIDTMVL PENFKDSRLK RKNLVKKVQV FLAECDTVEQ YICQETERLQ STNLALPE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.

Gene References into Functions

BAG1 expression increased progressively after sciatic nerve crush, reached a peak 2 weeks post-injury. It returned to the normal level 4 weeks post-injury. Spatially, BAG1 was mainly expressed in Schwann cells. PMID:23108487
After chronic adolescent stress, females displayed elevated hippocampal expression of Bag1 genes that was not observed in males. PMID:22647578
BAG-1 may play an important role in astrocytes proliferation after CNS injury. PMID:22526508
Shows that the human and mouse orthologs use alternative translation initiation codons, including a non-AUG(CUG) codon. PMID:9396724
These data suggest that storage temperatures, but not postmortem intervals, significantly affect the expression profile and cellular stability of Bag 1 proteins. PMID:17046197
BAG-1 has a role in supporting viability and matrix expression of chondrocytes PMID:17546604
Forced BAG1 expression within the nucleus when compared to full-length BAG1 expression and to control cells completely abolishes the neuroprotective effects of BAG1. PMID:18242589
These results clearly indicate that myocardial protection elicited by adaptation is mediated at least in part via up-regulation of autophagy in association with BAG-1 protein. PMID:18793351